ArticleJournal of endocrinological investigation2025
Insulin sensitivity index independently predicts serum IGF-1 decreases in adolescents with long-term exercise.
Article in Journal of endocrinological investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
backgroundThe study aims to investigate associations between insulin sensitivity and insulin-like growth factor-1 (IGF-1) in adolescents engaged in long-term exercise training, and to assess the impact on growth.
methodsWe conducted a prospective cohort study and followed for 1 year from a general high school (non-exercise group, age 13.3 ± 0.5 years, n = 149) and an exercise training school (exercise group, age 13.5 ± 1.3 years, n = 100). Growth indices, insulin sensitivity assessed using the Quantitative Insulin Sensitivity Check Index (QUICKI), and IGF-1 levels were obtained.
resultsParticipants in the exercise group exhibited higher QUICKI and lower IGF-1 levels. In the exercise group, IGF-1 was independently associated with QUICKI cross-sectionally at baseline and follow-up. Longitudinal analysis revealed that QUICKI at baseline was independently associated with IGF-1 levels at follow-up in the exercise group (β = -532.926, P = 0.032). Such associations were not found in non-exercise group. Additionally, no impairments in growth indices were observed in the exercise group.
conclusionsOur findings suggest that QUICKI is an independent predictor of IGF-1 levels in adolescents with a long-term exercise regimen.
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