Evidence map›Paper›PMID 40323663›Full record

ArticleJournal of the American Society of Nephrology : JASN2025

Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci.

Joanne B Cole, Emma H Dahlström, Damian Fermin, Yogesh Gupta, Claire Hill, Laura J Smyth, Hongbo Liu, Raymond J Kreienkamp, Marcus G Pezzolesi, Jing Jing Cao and 42 more

Abstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Exome-Wide Analysis Identifies a RareKidney international reports · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

52 authors.

Joanne B ColeDepartment of Biomedical Informatics, University of Colorado School of Medicine, Aurora, Colorado.ORCID 0000-0001-9520-2788
Emma H DahlströmFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.ORCID 0000-0003-1271-8696
Damian FerminDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-0548-3967
Yogesh GuptaCentre for Public Health, School of Medicine, Dentistry and Biomedical Science, Royal Victoria Hospital, Queen's University Belfast, Belfast, Northern Ireland.ORCID 0000-0003-4569-1741
Claire HillCentre for Public Health, School of Medicine, Dentistry and Biomedical Science, Royal Victoria Hospital, Queen's University Belfast, Belfast, Northern Ireland.ORCID 0000-0002-2481-5162
Laura J SmythCentre for Public Health, School of Medicine, Dentistry and Biomedical Science, Royal Victoria Hospital, Queen's University Belfast, Belfast, Northern Ireland.ORCID 0000-0001-6419-4826
Hongbo LiuRenal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-0733-8616
Raymond J KreienkampPrograms in Metabolism and Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.ORCID 0000-0002-1683-323
Marcus G PezzolesiDivision of Nephrology and Hypertension, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah.
Jing Jing CaoThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-9524-9567
Erkka ValoFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.ORCID 0000-0003-0672-554
Wei-Min ChenDepartment of Genome Sciences, University of Virginia, Charlottesville, Virginia.
Suna Onengut-GumuscuDepartment of Genome Sciences, University of Virginia, Charlottesville, Virginia.ORCID 0000-0002-6563-8334
Stephen S RichDepartment of Genome Sciences, University of Virginia, Charlottesville, Virginia.ORCID 0000-0003-3872-7793
Eoin P BrennanDiabetes Complications Research Centre, School of Medicine, UCD Conway Institute, University College Dublin, Dublin, Ireland.ORCID 0000-0003-4908-5474
Darrell AndrewsDiabetes Complications Research Centre, School of Medicine, UCD Conway Institute, University College Dublin, Dublin, Ireland.ORCID 0000-0002-3452-6858
Ciarán KennedyDiabetes Complications Research Centre, School of Medicine, UCD Conway Institute, University College Dublin, Dublin, Ireland.ORCID 0000-0003-1967-8754
Harvest F GuSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, China.ORCID 0000-0003-4578-5449
Lars StechemesserDepartment of Internal Medicine 1, Paracelsus Medical University, Salzburg, Austria.
Raimund WeitgasserCompetence Centre Diabetes, Diakonissen-Wehrle Hospital, Salzburg, Austria.
Jelizaveta SokolovskaFaculty of Medicine and Life Sciences, University of Latvia, Riga, Latvia.ORCID 0000-0003-0448-8229
Lina RadzevicieneInstitute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunus, Lithuania.ORCID 0000-0001-5008-9953
Rasa VerkauskieneInstitute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunus, Lithuania.ORCID 0000-0002-0108-9305
Nicolae M PanduruCarol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Peter RossingSteno Diabetes Center Copenhagen, Herlev, Denmark.ORCID 0000-0002-1531-4294
Tarunveer S AhluwaliaSteno Diabetes Center Copenhagen, Herlev, Denmark.ORCID 0000-0002-7464-3354
Gianpaolo ZerbiniDivision of Immunology, Transplantation and Infectious Diseases, Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milano, Italy.ORCID 0000-0001-6181-089
Michel MarreInstitut Necker Enfants Malades, Paris, France.
Samy HadjadjDepartment of Endocrinology, L'institut du thorax, INSERM,CHU Nantes, CNRS, Nantes Université, Nantes, France.ORCID 0000-0001-7110-6994
Tina CostacouDepartment of Epidemiology, University of Pittsburgh Public Health, Pittsburgh, Pennsylvania.ORCID 0000-0001-9303-3810
Rachel G MillerDepartment of Epidemiology, University of Pittsburgh Public Health, Pittsburgh, Pennsylvania.ORCID 0000-0003-1845-8477
Barbara E KleinDepartment of Ophthalmology and Visual Science, University of Wisconsin-Madison, Madison, Wisconsin.
Kristine E LeeDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin.ORCID 0000-0002-9102-4627
Janet K Snell-BergeonDepartment of Pediatrics, Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado.ORCID 0000-0002-9337-3740
Maria Luiza CaramoriDepartment of Endocrinology and Metabolism, Cleveland Clinic Foundation, Cleveland, Ohio.ORCID 0000-0001-6082-5934
Michael MauerDivisions of Nephrology, Departments of Pediatrics and Medicine, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0001-7301-9616
Kerstin BrismarDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-5241-514
Petter BjornstadDivision of Metabolism, Endocrinology, and Nutrition, School of Medicine, University of Washington, Seattle, Washington.
Amy J McKnightCentre for Public Health, School of Medicine, Dentistry and Biomedical Science, Royal Victoria Hospital, Queen's University Belfast, Belfast, Northern Ireland.ORCID 0000-0002-7482-709
Gareth McKayCentre for Public Health, School of Medicine, Dentistry and Biomedical Science, Royal Victoria Hospital, Queen's University Belfast, Belfast, Northern Ireland.ORCID 0000-0001-8197-6280
Viji NairDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Rany M SalemDivision of Epidemiology, Department of Family Medicine and Public Health, University of California San Diego, San Diego, California.ORCID 0000-0001-8816-6862
Per-Henrik GroopFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.ORCID 0000-0003-4055-6954
Catherine GodsonDiabetes Complications Research Centre, School of Medicine, UCD Conway Institute, University College Dublin, Dublin, Ireland.
Katalin SusztakRenal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-1005-3726
Matthias KretzlerDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0003-4064-0582
Alexander P MaxwellCentre for Public Health, School of Medicine, Dentistry and Biomedical Science, Royal Victoria Hospital, Queen's University Belfast, Belfast, Northern Ireland.ORCID 0000-0002-6110-7253
Andrzej KrolewskiSection on Genetic and Epidemiology, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-1705-2953
Andrew PatersonThe Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-9169-118
Niina Sandholm-LafferreFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.ORCID 0000-0003-4322-6942
Jose C FlorezPrograms in Metabolism and Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Joel N HirschhornPrograms in Metabolism and Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5M
VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI JOSHUA D RABINOWITZ · 1986 to 2026
$48.3M
EPIDEMIOLOGY OF DIABETIC COMPLICATIONS--PHASE IIR01DK034818 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COSTACOU, TINA · 1986 to 2019
$5.6M
University of Michigan O'Brien Kidney Translational Resource Center (MKTC)U54DK137314 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Salim Hayek · 2023 to 2026
$4.7M
A functional genomics pipeline for genetic discovery in diabetic kidney diseaseR01DK132299 · NIDDK · BROAD INSTITUTE, INC. · PI JOSE CARLOS FLOREZ, JOEL N HIRSCHHORN · 2022 to 2026
$3.2M
Integrative genomic, epigenetic and functional studies in diabetic kidney diseaseR01DK105154 · NIDDK · BROAD INSTITUTE, INC. · PI FLOREZ, JOSE CARLOS, HIRSCHHORN, JOEL N · 2016 to 2019
$3.0M
Mentoring Investigators on the Clinical Translation of Cardiometabolic Genetic DiscoveriesK24HL157960 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2021 to 2025
$626k
George M. O'Brien Michigan Kidney Translational Resource Center NIH/NIDDK U54DK137314NHLBI NIH HHS K24 HL157960NIDDK NIH HHS P30 DK019525NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK034818NIDDK NIH HHS R01 DK105154NIDDK NIH HHS R01 DK132299Science Foundation Ireland 15/IA/3152US Ireland R & D partnership award US IRL 2022-1-HRB
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

diabetic kidney diseaseGFRhuman genetics

Identifiers

PMID40323663
PMCPMC12499614

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.