Effects of Prebiotics and a Synthetic Microbiome Consortium on the Composition and Metabolites of the Elderly Gut Microbiota In Vitro.

Huimin Ye, Dara Meehan, Suzanne Timmons, Paul W O'Toole

Abstract read

In one paragraph

Article in Journal of agricultural and food chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Iron-saturated bovine lactoferrin preserves microbiota diversity and healthy ageing-associated taxa in an in vitro colon model of elderly gut microbiota (Iron-saturated bovine lactoferrin impact on elderly gut microbiota).PloS one · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Huimin YeSchool of Microbiology, and APC Microbiome Ireland, University College Cork, Western Road, T12 Y337 Cork, Ireland.ORCID 0000-0002-4706-9852

Dara MeehanSchool of Microbiology, and APC Microbiome Ireland, University College Cork, Western Road, T12 Y337 Cork, Ireland.

Suzanne TimmonsCentre for Gerontology and Rehabilitation, School of Medicine, University College Cork, Western Road, T12 Y337 Cork, Ireland.

Paul W O'TooleSchool of Microbiology, and APC Microbiome Ireland, University College Cork, Western Road, T12 Y337 Cork, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 24 h artificial colon fermentation was performed to assess the effects of a prebiotic MIX and synthetic consortium (S7) on gut microbiota composition and microbial metabolite production in clinically stratified older adults (healthy and frail). Treatments included supplementation of the donor microbiota with a synthetic microbial consortium (S7), a prebiotic mix (MIX), and a combination of MIX and S7 (MIX+S7). The S7 treatment decreased the alpha diversity of long-stay-dwelling donor (LS, "frail") microbiota and increased the relative abundance of S7 taxa at 16 h. MIX alone caused the enrichment of reportedly beneficial genera such as

Indexed as

BacteriaGastrointestinal MicrobiomeMicrobial ConsortiaPrebioticsAgedAged, 80 and overFatty Acids, VolatileFecesFemaleFermentationHumansMaleFatty Acids, VolatilePrebioticsagingcolon modelgut microbiotaolder personprebioticssynthetic consortium

Identifiers

PMID40324006

DOI10.1021/acs.jafc.5c00364

PMCPMC12082690

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.