Evidence map›Paper›PMID 40324079›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Structure and nucleic acid interactions of the S

Yang Yang, Loïc Delcourte, Carolanne van Belleghem, Simone Fonte, Kassandra Gerard, Sonia Baconnais, Morgane Callon, Eric Le Cam, Marie-Laure Fogeron, Massimo Levrero and 3 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Structural characterization of the HDV virion and its ribonucleoprotein.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yang YangMolecular Microbiology and Structural Biochemistry UMR 5086 CNRS/Université de Lyon, Labex Ecofect, Lyon 69367, France.ORCID 0009-0004-4545-410X
Loïc DelcourteMolecular Microbiology and Structural Biochemistry UMR 5086 CNRS/Université de Lyon, Labex Ecofect, Lyon 69367, France.
Carolanne van BelleghemMolecular Microbiology and Structural Biochemistry UMR 5086 CNRS/Université de Lyon, Labex Ecofect, Lyon 69367, France.
Simone FonteInstitut hospitalo-universitaire (IHU) EVEREST, Institute of Hepatology Lyon, Lyon 69004, France.ORCID 0000-0002-2419-3025
Kassandra GerardLaboratoire de Physique, Ecole Normale Supérieure de Lyon, UMR CNRS 5672, Lyon 69342, France.ORCID 0009-0000-4773-4464
Sonia BaconnaisGenome Integrity and Cancer UMR 9019 CNRS, Université Paris-Saclay - Gustave Roussy, Villejuif 94805, France.
Morgane CallonMolecular Microbiology and Structural Biochemistry UMR 5086 CNRS/Université de Lyon, Labex Ecofect, Lyon 69367, France.ORCID 0000-0002-0618-2293
Eric Le CamGenome Integrity and Cancer UMR 9019 CNRS, Université Paris-Saclay - Gustave Roussy, Villejuif 94805, France.
Marie-Laure FogeronMolecular Microbiology and Structural Biochemistry UMR 5086 CNRS/Université de Lyon, Labex Ecofect, Lyon 69367, France.
Massimo LevreroInstitut hospitalo-universitaire (IHU) EVEREST, Institute of Hepatology Lyon, Lyon 69004, France.ORCID 0000-0002-4978-0875
Cendrine Faivre-MoskalenkoLaboratoire de Physique, Ecole Normale Supérieure de Lyon, UMR CNRS 5672, Lyon 69342, France.ORCID 0000-0002-2686-0995
Anja BöckmannMolecular Microbiology and Structural Biochemistry UMR 5086 CNRS/Université de Lyon, Labex Ecofect, Lyon 69367, France.
Lauriane LecoqMolecular Microbiology and Structural Biochemistry UMR 5086 CNRS/Université de Lyon, Labex Ecofect, Lyon 69367, France.ORCID 0000-0002-5995-3733

Funding

Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS) ECTZ143165Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS) ECTZ158948China Scholarship Council (CSC) 202008620095
6 · The paper itself

Abstract

Infection with hepatitis delta virus (HDV) causes the most severe form of viral hepatitis, affecting more than 15 million people worldwide. HDV is a small RNA satellite virus of the hepatitis B virus (HBV) that relies on the HBV envelope for viral particle assembly. The only specific HDV component is the ribonucleoprotein (RNP), which consists of viral RNA (vRNA) associated with the small (S) and large (L) delta antigens (HDAg). While the structure of the HDAg N-terminal assembly domain is known, here we address the structure of the remaining S

Indexed as

Hepatitis delta AntigensHepatitis Delta VirusRNA, ViralHumansModels, MolecularProtein BindingProtein DomainsHepatitis delta AntigensRNA, Viralacidic clusterhepatitis delta virusNMRprotein–RNA interactionS-HDAg

Identifiers

PMID40324079
PMCPMC12088457

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.