Evidence map›Paper›PMID 40324556›Full record

ArticleAmerican journal of ophthalmology2025

Natural History of Microperimetry and Optical Coherence Tomography in USH2A-Retinopathy: A Structure-Function Association Study.

Ajoy Vincent, Wendi Liang, Maureen G Maguire, Jacque L Duncan, Allison R Ayala, Paul S Bernstein, Joseph Carroll, Janet K Cheetham, Todd A Durham, Sina Farsiu and 11 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ajoy VincentFrom the Departments of Ophthalmology and Vision Sciences (A.V.), The Hospital for Sick Children, The University of Toronto, Toronto, Ontario, Canada.
Wendi LiangJaeb Center for Health Research (W.L., M.G.M., A.R.A.), Tampa, Florida, USA.
Maureen G MaguireJaeb Center for Health Research (W.L., M.G.M., A.R.A.), Tampa, Florida, USA.
Jacque L DuncanUniversity of California (J.L.D.), San Francisco, California, USA.
Allison R AyalaJaeb Center for Health Research (W.L., M.G.M., A.R.A.), Tampa, Florida, USA. Electronic address: ffbcorrespauth@jaeb.org.
Paul S BernsteinMoran Eye Center, University of Utah (P.S.B.), Salt Lake City, Utah, USA.
Joseph CarrollDepartment of Ophthalmology and Visual Sciences (J.C.), Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Janet K CheethamFoundation Fighting Blindness (J.K.C., T.A.D.), Columbia, Maryland, USA.
Todd A DurhamFoundation Fighting Blindness (J.K.C., T.A.D.), Columbia, Maryland, USA.
Sina FarsiuDepartment of Ophthalmology (S.F., G.J.J., J.L., E.M.L.), Duke University, Durham, North Carolina, USA; Department of Biomedical Engineering (S.F., Z.Z.Z.), Duke University, Durham, North Carolina, USA.
Carel B HoyngRadboud University (C.B.H.), Nijmegen, Netherlands.
Rachel M HuckfeldtMassachusetts Eye and Ear (R.M.H.), Boston, Massachusetts, USA.
Glenn J JaffeDepartment of Ophthalmology (S.F., G.J.J., J.L., E.M.L.), Duke University, Durham, North Carolina, USA.
Jessica LooDepartment of Ophthalmology (S.F., G.J.J., J.L., E.M.L.), Duke University, Durham, North Carolina, USA.
Mark E PennesiCasey Eye Institute, Oregon Health and Science University (M.E.P., D.G.B.), Portland, Oregon, USA; Retina Foundation of the Southwest (M.E.P.), Dallas, Texas, USA.
José-Alain SahelInstitut de la Vision (J.A.S.), Sorbonne Université, INSERM, CNRS, Paris, France; Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (J.A.S.), Centre de Référence Maladies Rares REFERET, Paris, France; Department of Ophthalmology (J.A.S.), The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Mandeep S SinghWilmer Eye Institute (M.S.S.), Johns Hopkins Hospital, Baltimore, Maryland, USA; Department of Genetic Medicine (M.S.S.), Johns Hopkins University, Baltimore, Maryland, USA.
Zane Z ZemborainDepartment of Biomedical Engineering (S.F., Z.Z.Z.), Duke University, Durham, North Carolina, USA.
David G BirchCasey Eye Institute, Oregon Health and Science University (M.E.P., D.G.B.), Portland, Oregon, USA.
Eleonora M LadDepartment of Ophthalmology (S.F., G.J.J., J.L., E.M.L.), Duke University, Durham, North Carolina, USA.
Foundation Fighting Blindness Clinical Consortium Investigator Group

Funding

P30-CORE GRANT FOR VISION RESEARCHP30EY002162 · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · 1985 to 2005
$3.2M
NEI NIH HHS P30 EY002162
6 · The paper itself

Abstract

purposeTo describe the natural history of optical coherence tomography (OCT) and mesopic microperimetry (MP) parameters in the Rate of Progression of USH2A-related Retinal Degeneration (RUSH2A) study.

designMulticenter, international, prospective, longitudinal natural history study.

methodsStudy Population: 105 participants with biallelic disease-causing variants in USH2A with a clinical diagnosis of Usher Syndrome or autosomal recessive retinitis pigmentosa who underwent annual testing over 4 years. MAIN OUTCOME MEASURE(S): Ellipsoid zone (EZ) area and central sub-field thickness (CST) on OCT. Mean sensitivity (MS) and mean pointwise sensitivity at predefined functional transition points (MS

resultsA total of 101 and 94 participants met criteria for OCT and MP analysis, respectively. The average EZ area was 3.9 ± 5.3 mm

conclusionsThis study establishes the natural history of key structural and functional parameters in USH2A-retinopathy. The MS

Indexed as

Extracellular Matrix ProteinsRetinaRetinitis PigmentosaTomography, Optical CoherenceUsher SyndromesVisual FieldsVisual Field TestsAdolescentAdultChildDisease ProgressionFemaleFollow-Up StudiesHumansMaleMiddle AgedExtracellular Matrix ProteinsUSH2A protein, human

Identifiers

PMID40324556
PMCPMC13102027

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.