Not the same as it ever was: A review of memory modification, updating, and distortion in humans and rodents.

Memory is a reconstructive and continuous process that enables existing information to be modified in response to a changing environment. Being able to dynamically update outdated memories is critical to an organism's survival. Memory modifications have been extensively studied in both rodents and humans, and prior work has revealed many regional, cellular, neurotransmitter, and subcellular molecular mechanisms underlying this process. However, these diverse bodies of literature have not yet been fully integrated into a comprehensive cross-species review. Integrating the finding across rodent and human work is important for furthering our understanding of memory modifications and the underlying neural mechanisms that support memory modification in both species. Here, we discuss advances in our understanding of adaptive and maladaptive memory modifications in terms of both underlying mechanisms (regional, cellular, and molecular) and behavioral outcomes. By emphasizing findings from both humans and rodents, the two major model systems in which memory modifications have been studied, we are able to highlight converging mechanisms and point to open questions in the field. Specifically, we discuss the major findings from several memory paradigms including declarative, aversive and procedural memory designs and highlight paradigms and models that have been readily translated between rodent and human models. Ultimately, this review identifies key parallels underlying memory updating across species, paradigms, tasks, and models.