Evidence map›Paper›PMID 40324975›Full record

ArticleNature communications2025

Acoustofluidic bioassembly induced morphogenesis for therapeutic tissue fabrication.

Byungjun Kang, Eunseon Jeong, Seung Yeop Han, Jeong Hyun Heo, Yunam Lee, Suah Choi, Yunjung Choi, Donyoung Kang, Youn-Hoo Hwang, Jiin Lee and 11 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Micro/Nanoscale Acoustic Manipulation: From Particle Control to Autonomous Microswimmers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Byungjun Kang *School of Mechanical Engineering, Yonsei University, Seoul, 03722, Republic of Korea.ORCID http://orcid.org/0000-0001-7220-801X
Eunseon Jeong *Department of Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.ORCID http://orcid.org/0000-0003-0513-8693
Seung Yeop HanDepartment of Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
Jeong Hyun HeoDepartment of Physiology, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.ORCID http://orcid.org/0000-0002-9734-5376
Yunam LeeSchool of Mechanical Engineering, Yonsei University, Seoul, 03722, Republic of Korea.ORCID http://orcid.org/0009-0003-6833-8032
Suah ChoiDepartment of Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
Yunjung ChoiSchool of Mechanical Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
Donyoung KangSchool of Mechanical Engineering, Yonsei University, Seoul, 03722, Republic of Korea.ORCID http://orcid.org/0000-0003-2680-7489
Youn-Hoo HwangSchool of Mechanical Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
Jiin LeeDepartment of Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea.
Jung Hwa SeoDepartment and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.ORCID http://orcid.org/0000-0002-8489-7972
Jinyoung KimDepartment and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Inhea JeongDepartment of Materials Science and Engineering, Yonsei University, Seoul, 03722, Republic of Korea.ORCID http://orcid.org/0000-0003-2226-4755
Enji KimDepartment of Materials Science and Engineering, Yonsei University, Seoul, 03722, Republic of Korea.ORCID http://orcid.org/0000-0002-4934-8951
Juyoung LeeSchool of Mechanical Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
Dae-Eun KimSchool of Mechanical Engineering, Yonsei University, Seoul, 03722, Republic of Korea.ORCID http://orcid.org/0000-0002-6095-5138
Jang-Ung ParkDepartment of Materials Science and Engineering, Yonsei University, Seoul, 03722, Republic of Korea.ORCID http://orcid.org/0000-0003-1522-4958
Sung-Rae ChoDepartment and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.ORCID http://orcid.org/0000-0003-1429-2684
Yoonhee JinDepartment of Physiology, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Seung-Woo ChoDepartment of Biotechnology, Yonsei University, Seoul, 03722, Republic of Korea. seungwoocho@yonsei.ac.kr.ORCID http://orcid.org/0000-0001-8058-332X
Hyungsuk LeeSchool of Mechanical Engineering, Yonsei University, Seoul, 03722, Republic of Korea. hyungsuk@yonsei.ac.kr.ORCID http://orcid.org/0000-0002-7873-7163

Funding

National Research Foundation of Korea (NRF) 2021R1A2C2009070
6 · The paper itself

Abstract

To build in vitro tissues for therapeutic applications, it is essential to replicate the spatial distribution of cells that occurs during morphogenesis in vivo. However, it remains technically challenging to simultaneously regulate the geometric alignment and aggregation of cells during tissue fabrication. Here, we introduce the acoustofluidic bioassembly induced morphogenesis, which is the combination of precise arrangement of cells by the mechanical forces produced by acoustofluidic cues, and the morphological and functional changes of cells in the following in vitro and in vivo cultures. The acoustofluidic bioassembly can be used to create tissues with regulated nano-, micro-, and macro-structures. We demonstrate that the neuromuscular tissue fabricated with the acoustofluidic bioassembly exhibits enhanced contraction dynamics, electrophysiology, and therapeutic efficacy. The potential of the acoustofluidic bioassembly as an in situ application is demonstrated by fabricating artificial tissues at the defect sites of living tissues. The acoustofluidic bioassembly induced morphogenesis can provide a pioneering platform to fabricate tissues for biomedical applications.

Indexed as

AcousticsMorphogenesisTissue EngineeringAnimalsHumansMice

Identifiers

PMID40324975
PMCPMC12053659

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.