Evidence map›Paper›PMID 40325037›Full record

ArticleScientific reports2025

Disulfiram induces redox imbalance and perturbations in central glucose catabolism and metal homeostasis to inhibit the growth of Staphylococcus aureus.

Timothy E Long, Surya Teja Naidu, Emily G Hissom, Yogesh Meka, Hasitha Chavva, Kathleen C Brown, Meagan E Valentine, Jun Fan, James Denvir, Donald A Primerano and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Timothy E LongDepartment of Pharmaceutical Sciences, School of Pharmacy, Marshall University, Huntington, WV, USA. longt@marshall.edu.
Surya Teja NaiduDepartment of Pharmaceutical Sciences, School of Pharmacy, Marshall University, Huntington, WV, USA.
Emily G HissomDepartment of Pharmaceutical Sciences, School of Pharmacy, Marshall University, Huntington, WV, USA.
Yogesh MekaDepartment of Pharmaceutical Sciences, School of Pharmacy, Marshall University, Huntington, WV, USA.
Hasitha ChavvaDepartment of Pharmaceutical Sciences, School of Pharmacy, Marshall University, Huntington, WV, USA.
Kathleen C BrownDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Meagan E ValentineDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Jun FanDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.
James DenvirDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Donald A PrimeranoDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Hongwei D YuDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.
Monica A ValentovicDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA.

Funding

WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI GARY O RANKIN · 2012 to 2026
$61.1M
Discovery of Disulfiram as an Anti-MRSA Antibiotic AdjuvantR15AI151970 · NIAID · MARSHALL UNIVERSITY · PI LONG, TIMOTHY EDWARD · 2020 to 2020
$434k
National Institute of Allergy and Infectious Diseases R15AI151970NIAID NIH HHS R15 AI151970NIGMS NIH HHS P20 GM103434NIH HHS P20GM103434
6 · The paper itself

Abstract

Disulfiram (Antabuse

Indexed as

Anti-Bacterial AgentsDisulfiramGlucoseHomeostasisMetalsStaphylococcus aureusMetabolomicsOxidation-ReductionOxidative StressAnti-Bacterial AgentsDisulfiramGlucoseMetals

Identifiers

PMID40325037
PMCPMC12053631

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.