Evidence map›Paper›PMID 40325137›Full record

ArticleScientific reports2025

Obesity and acylcarnitine derivates interplay with coronary artery disease.

Tomasz Urbanowicz, Paweł Gutaj, Szymon Plewa, Ievgen Spasenenko, Anna Olasińska-Wiśniewska, Beata Krasińska, Andrzej Tykarski, Aleksandra Krasińska-Plachta, Łucja Pilaczyńska-Szcześniak, Zbigniew Krasiński and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tomasz UrbanowiczCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, Długa ½ Street, 61-848, Poznan, Poland. turbanowicz@ump.edu.pl.
Paweł GutajDepartment of Reproduction, Poznan University of Medical Sciences, Poznan, Poland.
Szymon PlewaDepartment of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland.
Ievgen SpasenenkoDepartment of Hypertensiology, Angiology and Internal Medicine, University of Medical Sciences, Długa ½ Street, 61-848, Poznan, Poland.
Anna Olasińska-WiśniewskaCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, Długa ½ Street, 61-848, Poznan, Poland.
Beata KrasińskaDepartment of Hypertensiology, Angiology and Internal Medicine, University of Medical Sciences, Długa ½ Street, 61-848, Poznan, Poland.
Andrzej TykarskiDepartment of Hypertensiology, Angiology and Internal Medicine, University of Medical Sciences, Długa ½ Street, 61-848, Poznan, Poland.
Aleksandra Krasińska-PlachtaDepartment of Ophtalmology, Poznan University of Medical Sciences, Fredry 10, 61-107, Poznan, Poland.
Łucja Pilaczyńska-SzcześniakFaculty of Health Sciences, University of Kalisz, Kaszubska 13 Street, 62-800, Kalisz, Poland.
Zbigniew KrasińskiDepartment of Vascular, Endovascular Surgery, Angiology and Phlebology Medical University, Poznan University of Medical Science, Długa ½ Street, 61-848, Poznan, Poland.
Ewelina GrywalskaDepartment of Experimental Immunology, Medical University of Lublin, Chodźki 4a Street, 20-093, Lublin, Poland.
Mansur RahnamaDepartment of Dental Surgery, Medical University of Lublin, Chodźki 6 Street, 20-093, Lublin, Poland.
Jan MatysiakDepartment of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland.
Ewa Wender-OżegowskaDepartment of Reproduction, Poznan University of Medical Sciences, Poznan, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronary artery disease (CAD) is common in patients burdened with metabolic syndrome. Increased risk of cardiovascular disease is associated with abnormal levels of acylated derivates of carnitine. The present study aimed to evaluate the possible association between carnitine derivatives and coronary artery disease, including obese individuals. Twenty consecutive patients presenting with dyspnea on exertion were enrolled in the prospective analysis for metabolomic profiling. They were divided into two groups regarding CAD presence. Six (60%) men and four (40%) women comprised the CAD group assigned as Group 1, while 6 (60%) men and 4 (40%) women with normal coronary arteries on angiograms as Group 2. Compared to the non-CAD group, the CAD group was characterized by lower levels of the sum of long-chain ACs (p = 0.024), the sum of short-chain ACs (p = 0.022), saturated fatty acids (SFA) (p = 0.030) and monounsaturated fatty acids (MUFA) (p = 0.022). Further subanalysis concerning patients' body mass index and CAD showed significant differences in plasma sum of ACs between the groups (p = 0.050) and SFA (p = 0.050) but not regarding the short-chain ACs (p = 0.060), medium-ACs (p = 0.758), long-chain-ACs (p = 0.141), or MUFA (p = 0.151). Our analysis revealed lower plasma levels of short-chain and saturated fatty acids acylcarnitine derivates in obese patients presenting with CAD.

Indexed as

CarnitineCoronary Artery DiseaseObesityAgedBody Mass IndexFatty AcidsFemaleHumansMaleMetabolomicsMiddle AgedProspective StudiesacylcarnitineCarnitineFatty AcidsAcylcarnitineCoronary artery diseaseObesity

Identifiers

PMID40325137
PMCPMC12053606

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.