GLP-1 receptor agonists × adverse events & safety

SynthesisAging clinical and experimental research2025

Comparative efficacy and safety of antidiabetic drugs for obese patients with knee osteoarthritis: a network meta-analysis of randomized controlled trials.

Guangyao Jiang et al.PubMed ↗Full text ↗Publisher ↗

  • Liraglutideno clear effectNo clear effect on serious adverse events.Nothing cleared the noise.
  • Semaglutideno clear effectNo clear effect on serious adverse events.Nothing cleared the noise.

What the trial testedas reported · 2025

Range includes no effect

No clear effect on serious adverse events

+0.09−0.74 to +0.92

liraglutide vs usual care

As reported

difference 0.09, 95% CI −0.74 to 0.92 · the paper's word: incidence of serious adverse events

Range includes no effect

No clear effect on serious adverse events

+0.21−0.46 to +0.88

semaglutide vs usual care

As reported

difference 0.21, 95% CI −0.46 to 0.88 · the paper's word: incidence of serious adverse events

Who was studied, and how

people with obesity, in this paper

The trial randomly assignedassigned by chance

liraglutide
usual care

No clear effect on serious adverse events+0.09

randomised

The trial randomly assignedassigned by chance

semaglutide
usual care

No clear effect on serious adverse events+0.21

randomised

the abstract, start to end

of adverse events, with liraglutide (0.09, 95% CI - 0.74, 0.92) and semaglutide (0.21, 95% CI - 0.46, 0.88) also

← favours treatmentfavours comparator →
could be chance
Incidence of serious adverse eventsliraglutide vs usual care
0.09−0.74 to 0.92
Incidence of serious adverse eventssemaglutide vs usual care
0.21−0.46 to 0.88
GLP-1 receptor agonistsAdverse events & safety

GLP-1 receptor agonists × adverse events & safetyharms?mixed

unlikelylikely
0.02not counted
← favours treatmentfavours comparator →
more certainless certain
1 / 6

2 papers cite it

2025
2026
this papercites it
Full record →Abstract, authors, funding and every citing paper · PMID 40325308