ArticleBMC medical imaging2025
Impact of glycemic control on brain microstructure in type 2 diabetes mellitus: insights from diffusion tensor imaging.
Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Altered cortical thickness in type 2 diabetes mellitus patients revealed by coordinate-based meta-analysis.BMC endocrine disorders · 2026Pooled it
- Diffusion Magnetic Resonance Imaging Models for Detecting Brain Microstructural Abnormalities in Type 2 Diabetes: A Systematic Review.Bioengineering (Basel, Switzerland) · 2026Review
- Imaging the therapeutic effects of cerebral endothelial cell derived exosome treatment of a preclinical model of Alzheimer's disease.Frontiers in aging neuroscience · 2026Article
- Epicenter mapping of cortical morphological dedifferentiation in type 2 diabetes mellitus using morphometric inverse divergence.Frontiers in aging neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundType 2 diabetes mellitus (T2DM) has been associated with brain microstructural alterations, potentially contributing to cognitive decline and neurodegeneration. Diffusion tensor imaging (DTI) provides a non-invasive method to assess these changes. However, the relationship between glycemic control and brain microstructural integrity remains unclear. This study aims to investigate the association between glycemic control and brain microstructural changes in T2DM using DTI.
methodsThis retrospective study included 90 participants (30 healthy controls, 60 T2DM patients) who underwent 1.5T MRI DTI at The Affiliated Shunde Hospital of Jinan University between January 2023 and May 2024. T2DM patients were categorized into well-controlled (HbA1c < 7%, n = 30) and poorly controlled (HbA1c ≥ 7%, n = 30) groups. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values were analyzed across multiple white matter regions. Pearson's correlation was used to assess associations between HbA1c and DTI metrics, while group differences were evaluated using Bayesian effect size estimation.
resultsHbA1c negatively correlated with ADC values in the right hippocampus (r = -0.33, p = 0.0013), suggesting a relationship between poor glycemic control and increased tissue diffusivity. A weak but significant positive correlation between HbA1c and FA in the right hippocampus (r = 0.23, p = 0.03) was observed. ADC values were higher in the poorly controlled T2DM group, indicating potential diabetes-related microstructural changes. No significant FA or ADC differences were found in other brain regions (p > 0.05).
conclusionsPoor glycemic control in T2DM is associated with microstructural alterations in the right hippocampus, potentially reflecting early neurodegenerative processes. Longitudinal studies are needed to further investigate these findings.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.