ArticleJournal of internal medicine2025
Adverse effects of obesity on overall health, quality of life, and related physical health metrics: A cross-sectional and longitudinal study from the All of Us Research Program.
Article in Journal of internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- The Association Between Obesity Class and Cause-Specific Mortality by Age and Sex in US Adults.Clinical obesity · 2026Article
- Liver Transplantation in the Era of Metabolic Bariatric Surgery: A Bibliometric Analysis.Obesity surgery · 2026Review
- Article
- The important role of comorbidities in the management of obesity.Journal of the Endocrine Society · 2026Review
- Reimagining obesity analyses: the need for new approaches to study obesity-related multimorbidity and event cascades.American journal of preventive cardiology · 2025Article
- Central obesity rather than BMI is associated with chronic pain: A cross-sectional analysis of NHANES.PloS one · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundPopulation-level adverse effects of obesity beyond commonly considered chronic conditions need to be characterized to understand its overall burden.
objectiveTo assess the cross-sectional associations between obesity and self-reported status of overall health, quality of life, pain, fatigue, ability of physical activity, and the risks of developing chronic pain syndrome, chronic fatigue syndrome, fibromyalgia, and insomnia.
methodsUsing data from the All of Us Research Program (the United States), we included participants with a body mass index (BMI) ≥18.5 kg/m
resultsAmong 323,640 participants (60.3% were female, mean age: 51.3 years), 20.7%, 11.0%, and 9.5% were with Classes I, II, and III obesity, respectively. Higher BMI categories were correlated with worse health metrics, with Class III obesity exhibiting the greatest disparities. Among those with Class III obesity, 9.6% (vs. 3.2% for normal weight) reported poor overall health, 28.3% (vs. 13.2%) reported severe pain, and 11.8% (vs. 8.4%) had prevalent insomnia. Graded associations were observed across high BMI categories, with Class III obesity showing the strongest effects. Compared with normal weight, in Class III obesity, the odds ratio (95% CI) was 3.82 (3.69-3.96) for fair/poor overall health, 3.93 (3.71-4.17) for severe pain, and 3.13 (2.98-3.29) for severely limited physical activity; the hazard ratio (95% CI) was 2.83 (2.36-3.40) for fibromyalgia and 1.53 (1.41-1.65) for insomnia.
conclusionObesity imposes a substantial burden on broad aspects of well-being in the US population.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.