Evidence map›Paper›PMID 40325985›Full record

ArticleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2025

Thrombus characterisation and evolution of hypoattenuating leaflet thickening after transcatheter aortic valve implantation.

Kajetan Grodecki, Damini Dey, Jolien Geers, Jacek Kwiecinski, Guadalupe Flores Tomasino, Vivek Patel, Caroline Park, Emily Xing, Dhairya Patel, Kazuki Suruga and 8 more

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In one paragraph

Article in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kajetan GrodeckiDepartments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Damini DeyDepartments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jolien GeersDepartments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jacek KwiecinskiDepartments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Guadalupe Flores TomasinoDepartments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Vivek PatelDivision of Cardiology, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Caroline ParkDepartments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Emily XingDepartments of Biomedical Sciences and Medicine, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Dhairya PatelDivision of Cardiology, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Kazuki SurugaDivision of Cardiology, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Aakriti GuptaDivision of Cardiology, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Mamoo NakamuraDivision of Cardiology, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Mitch GheorghiuDivision of Cardiology, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Tarun ChakravartyDivision of Cardiology, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Daniel BermanDepartment of Medicine (Division of Artificial Intelligence in Medicine), Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Piotr SlomkaDepartment of Medicine (Division of Artificial Intelligence in Medicine), Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Hasan JilaihawiDivision of Cardiology, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Raj R MakkarDivision of Cardiology, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Funding

AI-enabled characterization of fibrocalcific aortic valve disease and inflammation from CT Angiography: Patient-specific outcome predictionR01HL175875 · CEDARS-SINAI MEDICAL CENTER · 2025 to 2025
$789k
NHLBI NIH HHS R01 HL175875
6 · The paper itself

Abstract

backgroundQuantifying hypoattenuating leaflet thickening (HALT) on computed tomography angiography (CTA) may provide insights into its clinical implications and guide decisions on oral anticoagulation therapy following transcatheter aortic valve implantation (TAVI).

aimsWe sought to assess the association between quantitative CTA features of HALT and its evolution over time in a real-world cohort after TAVI.

methodsAmong 612 patients who underwent CTA 30 days post-TAVI with balloon-expandable bioprostheses, HALT was detected in 118 (19%). We prospectively followed 99 patients who had undergone a second CTA at 1 year to assess HALT progression. Thrombus volume and mean attenuation were quantified using semiautomated software, and various parameters of bioprosthetic deformation were analysed.

resultsComplete resolution of HALT was observed in 43 patients. Multivariate logistic regression showed that lower thrombus attenuation was an independent predictor of HALT resolution (odds ratio [OR] 0.45; p=0.030), along with the eccentricity index (OR 0.42; p=0.003), deformation index (OR 0.53; p=0.005), and implant canting (OR 1.88; p=0.026). In the 56 patients without complete HALT resolution, thrombus evolution was visually categorised as regression (48%), stability (29%), or progression (23%). In a quantitative assessment, regression was associated with a significant decrease in thrombus volume (291 mm³ to 130 mm³; p=0.007), while progression showed an increase (187 mm³ to 667 mm³; p=0.005). The change in thrombus volume between 30 days and 1 year correlated with the magnitude of changes in mean transvalvular gradients over the same period (r=0.462; p<0.001).

conclusionsQuantitative thrombus characterisation on CTA is predictive of HALT resolution and correlates with the haemodynamic performance of transcatheter aortic valves.

Indexed as

Aortic ValveAortic Valve StenosisComputed Tomography AngiographyThrombosisTranscatheter Aortic Valve ReplacementAgedAged, 80 and overBioprosthesisFemaleHeart Valve ProsthesisHumansMaleProspective StudiesTreatment Outcome

Identifiers

PMID40325985
PMCPMC12038363

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.