Evidence map›Paper›PMID 40326152›Full record

ArticleAdvanced healthcare materials2025

Encapsulation of Small Extracellular Vesicles into Selectively Disassemblable Shells of PEGylated Metal-Phenolic Networks.

Chenyu Wang, Ailifeire Fulati, Kenta Kimura, Xianglan Li, Joseph J Richardson, Mitsuru Naito, Kanjiro Miyata, Takanori Ichiki, Hirotaka Ejima

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chenyu WangDepartment of Materials Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
Ailifeire FulatiDepartment of Advanced Materials Science, Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba, 277-8561, Japan.
Kenta KimuraDepartment of Materials Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
Xianglan LiMaterials Fabrication and Analysis Platform, Research Network and Facility Services Division, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki, 305-0044, Japan.
Joseph J RichardsonDepartment of Chemical and Environmental Engineering, RMIT University, Melbourne, Victoria, 3000, Australia.ORCID https://orcid.org/0000-0001-8618-4127
Mitsuru NaitoDepartment of Materials Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.ORCID https://orcid.org/0000-0002-4237-871X
Kanjiro MiyataDepartment of Materials Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.ORCID https://orcid.org/0000-0001-7044-190X
Takanori IchikiDepartment of Materials Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.ORCID https://orcid.org/0000-0002-3917-7140
Hirotaka EjimaDepartment of Materials Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.ORCID https://orcid.org/0000-0002-4965-9493

Funding

"Advanced Research Infrastructure for Materials and Nanotechnology in JapanAustralian Government.Australian Research Council Future Fellowship FT210100669Japan Science and Technology AgencyJapan Science and Technology Corporation JPMJPR21N4Japan Society for the Promotion of Science London 20F20373Japan Society for the Promotion of Science London 20H02581Japan Society for the Promotion of Science London 20K20641Ministry of Education, Culture, Sports, Science and Technology (MEXT) JPMXP1224UT0117Mitsubishi Foundation and Asahi Glass FoundationNIMS Molecule & Material Synthesis Platform in the "Nanotechnology Platform Project" operated by the Ministry of Education, Culture, Sports, Science and Technology
6 · The paper itself

Abstract

Small extracellular vesicles (sEVs) are cell-derived particles used for intercellular communication in living organisms that have gained great interest from researchers for their use as drug carriers and diagnostic agents. However, the isolation and storage of sEVs lead to issues including lipid membrane disruption, protein denaturation, and nucleic acid degradation. Herein, a surface functionalization strategy is reported for encapsulating single sEV into selectively disassemblable protective shells composed of metal-phenolic networks (MPNs) post-modified with poly(ethylene glycol) (PEG). Disassemblable MPN shells can be rapidly deposited on sEVs in a one-step manner and post-modified with PEG. These coatings enhance the colloidal stability of sEVs and protect them against harsh storage conditions, while the non-covalent and selectively disassemblable nature of the MPN shell allows recovery after storage without compromising their surface integrity and functionality. It is demonstrated that various triggers, such as pH adjustment, competitive chelation, and redox reactions, can be used to disassemble the MPN shell, thereby offering widely adoptable strategies depending on the target applications. This approach potentially overcomes conventional challenges associated with sEV processing and storage and may contribute to reducing cold-chain requirements and transportation costs of future sEVs-based therapeutics and diagnostics.

Indexed as

Extracellular VesiclesMetalsPhenolsPolyethylene GlycolsHumansMetalsPhenolsPolyethylene Glycolsdisassemblable coatingexosomeMPNsone‐step assemblystorage stabilitysurface functionalizationsurface PEGylation

Identifiers

PMID40326152
PMCPMC12264842

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.