Evidence map›Paper›PMID 40326229›Full record

ArticleCytoskeleton (Hoboken, N.J.)2026

The NLS3 Motif in TPX2 Regulates Spindle Architecture in Xenopus Egg Extracts.

Guadalupe E Pena, Xiao Zhou, Lauren Slevin, Christopher Brownlee, Rebecca Heald

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cytoskeleton (Hoboken, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Guadalupe E PenaDepartment of Molecular and Cell Biology, University of California, Berkeley, California, USA.
Xiao ZhouDepartment of Molecular and Cell Biology, University of California, Berkeley, California, USA.
Lauren SlevinDepartment of Molecular and Cell Biology, University of California, Berkeley, California, USA.
Christopher BrownleeDepartment of Molecular and Cell Biology, University of California, Berkeley, California, USA.
Rebecca HealdDepartment of Molecular and Cell Biology, University of California, Berkeley, California, USA.

Funding

Mechanisms of mitosis and size control in XenopusR35GM118183 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEALD, REBECCA W · 2016 to 2025
$8.2M
NIGMS NIH HHS R35 GM118183NIH HHS
6 · The paper itself

Abstract

A bipolar spindle composed of microtubules and many associated proteins functions to segregate chromosomes during cell division in all eukaryotes, yet both spindle size and architecture vary dramatically across different species and cell types. Targeting protein for Xklp2 (TPX2) is one candidate factor for modulating spindle microtubule organization through its roles in branching microtubule nucleation, activation of the mitotic kinase Aurora A, and association with the kinesin-5 (Eg5) motor. Here we characterize a conserved nuclear localization sequence (NLS) motif,

Indexed as

Cell Cycle ProteinsMicrotubule-Associated ProteinsNuclear Localization SignalsNuclear ProteinsOvumSpindle ApparatusXenopus ProteinsAnimalsMicrotubulesXenopus laevisCell Cycle ProteinsMicrotubule-Associated ProteinsNuclear Localization SignalsNuclear ProteinsTPX2 protein, XenopusXenopus Proteinscell divisionmicrotubulespindleTPX2

Identifiers

PMID40326229
PMCPMC12353509

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.