Evidence map›Paper›PMID 40326486›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2025

Treatment With Inhaled Nitric Oxide and General Intelligence in Preterm Children in Two European Cohorts.

Nicole Tsalacopoulos, Valérie Benhammou, Laetitia Marchand-Martin, Véronique Pierrat, Pierre-Yves Ancel, Armita Shahesmaeilinejad, Viktoria Rücker, Vincent Prevot, Konstantina Chachlaki, Christoph Härtel and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nicole TsalacopoulosDepartment of Pediatrics, University Hospital Würzburg, Würzburg, Germany.
Valérie BenhammouEpidemiology and Statistics Research Center/CRESS, INSERM, INRAE, Paris Cité University, Paris, France.
Laetitia Marchand-MartinEpidemiology and Statistics Research Center/CRESS, INSERM, INRAE, Paris Cité University, Paris, France.
Véronique PierratEpidemiology and Statistics Research Center/CRESS, INSERM, INRAE, Paris Cité University, Paris, France.ORCID https://orcid.org/0000-0001-7435-5144
Pierre-Yves AncelEpidemiology and Statistics Research Center/CRESS, INSERM, INRAE, Paris Cité University, Paris, France.
Armita ShahesmaeilinejadInstitute for Medical Data Science, University Hospital Würzburg, Würzburg, Germany.
Viktoria RückerInstitute of Clinical Epidemiology and Biometry, Julius-Maximilians-University of Würzburg, Würzburg, Germany.
Vincent PrevotLaboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, University Lille, Inserm, CHU Lille, Lille, France.
Konstantina ChachlakiLaboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition, University Lille, Inserm, CHU Lille, Lille, France.
Christoph HärtelDepartment of Pediatrics, University Hospital Würzburg, Würzburg, Germany.
Wolfgang GöpelDepartment of Pediatrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.ORCID https://orcid.org/0000-0002-6486-4727
Juliane SpieglerDepartment of Pediatrics, University Hospital Würzburg, Würzburg, Germany.
miniNO Consortium

Funding

Apicil Foundation R20065KKBundesministerium für Bildung und Forschung 01ER0805Bundesministerium für Bildung und Forschung 01ER1501European Commission 847941Fondation de France 11779Fondation pour la Recherche Médicale SPF20160936356French Institute of Public Health Research/Institute of Public Health and its partners: the French Health Ministry, the National Institutes of Health and Medical Research (INSERM), the National Institute of Cancer, and the National Solidarity Fund for Autonomy (CNSA)Ministére de l'Enseignement Supérieur, De La Recherche et de L'Innovation G13129KKNational Research Agency through the French EQUIPEX program of investments in the future ANR-11-EQPX-0038National Research Agency through the French EQUIPEX program of investments in the future ANR-19-COHO001PREMUP FoundationProgram Hospitalier de Recherche Clinique Epinutri DGOS13-040
6 · The paper itself

Abstract

aimTo investigate whether treatment with inhaled nitric oxide is associated with cognitive performance at age 5-6 years in preterm-born children.

methodsWe analysed preterm children from two large European cohort studies, the German Neonatal Network (GNN) (N = 3606) and the French EPIPAGE-2 cohort (N = 2579) admitted to neonatal care and followed up at age 5-6 years. Both cohorts had recorded data on iNO treatment. General cognitive ability was tested with IQ tests. Classification and Regression trees analysis was used to identify prenatal, perinatal and neonatal, clinical and social-environmental predictors of IQ.

resultsIn both cohorts, treatment with inhaled nitric oxide was not associated with IQ at age 5-6 years. Analysis identified maternal educational level, gestational age at discharge from hospital, intraventricular haemorrhage and maternal country of birth as important factors associated with IQ scores.

conclusionTreatment with inhaled nitric oxide was neither negatively nor positively associated with IQ at age 5-6 years. Neonatal and brain health, as well as socioeconomic factors are important for cognitive performance in early childhood.

Indexed as

IntelligenceNitric OxideAdministration, InhalationChildChild, PreschoolCohort StudiesFemaleHumansInfant, NewbornInfant, PrematureMaleNitric Oxidecognitive functioninhaled nitric oxideIQminipubertypreterm birth

Identifiers

PMID40326486
PMCPMC12336939

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.