ArticleJournal of extracellular vesicles2025
Heat Shock Strengthens the Protective Potential of MSCs in Liver Injury by Promoting EV Release Through Upregulated Autophagosome Formation.
Abstract read
In one paragraph
Article in Journal of extracellular vesicles, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Letter to the Editor: Low-energy fractional carbon dioxide laser priming of mesenchymal stem cell-derived exosomes: A photothermal boost for diabetic wound angiogenesis.World journal of methodology · 2026Article
- Vitamin A-coupled MSCs- derived extracellular vesicles relieve acute liver injury by targeting hepatic stellate cells to deliver REDD1.Journal of nanobiotechnology · 2026Article
- Engineered NestinJournal of extracellular vesicles · 2026Article
- Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Mesenchymal stem cell-derived extracellular vesicles attenuate liver transplantation-induced ischemia/reperfusion injury by suppressing hepatocellular complement C5 expression.Journal of nanobiotechnology · 2026Article
- Heat Shock Strengthens the Protective Potential of MSCs in Liver Injury by Promoting EV Release Through Upregulated Autophagosome Formation.Journal of extracellular vesicles · 2025Article
- Mesenchymal Stem Cell-Derived Extracellular Vesicles in Alzheimer's Disease: A Novel Cell-Free Therapeutic Strategy and Diagnostic Biomarker.International journal of nanomedicine · 2025Review
- Harnessing mesenchymal stromal cells for liver disease therapy: from mechanistic discoveries to clinical breakthroughs.Frontiers in medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Tingting WangOrgan Transplantation Research Center of Guangdong Province, Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Engineering Laboratory for Transplantation Medicine, Guangzhou, China.
Yihang GongOrgan Transplantation Research Center of Guangdong Province, Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Engineering Laboratory for Transplantation Medicine, Guangzhou, China.
Huizhu LinBiological Treatment Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Xuejiao LiGuangdong Provincial Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Jinliang LiangGuangdong Provincial Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Xiaofeng YuanDepartment of General Intensive Care Unit, Lingnan Hospital, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Cuiping LiBiological Treatment Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhongying HuGuangdong Provincial Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Haitian ChenOrgan Transplantation Research Center of Guangdong Province, Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Engineering Laboratory for Transplantation Medicine, Guangzhou, China.
Jiaqi XiaoOrgan Transplantation Research Center of Guangdong Province, Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Engineering Laboratory for Transplantation Medicine, Guangzhou, China.
Jiebin ZhangOrgan Transplantation Research Center of Guangdong Province, Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Engineering Laboratory for Transplantation Medicine, Guangzhou, China.
Yasong LiuOrgan Transplantation Research Center of Guangdong Province, Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Engineering Laboratory for Transplantation Medicine, Guangzhou, China.
Xijing YanDepartment of Breast and Thyroid Surgery, Lingnan Hospital, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Chenhao JiangOrgan Transplantation Research Center of Guangdong Province, Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Engineering Laboratory for Transplantation Medicine, Guangzhou, China.
Jia YaoOrgan Transplantation Research Center of Guangdong Province, Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Engineering Laboratory for Transplantation Medicine, Guangzhou, China.
Qi ZhangBiotherapy Centre & Cell-gene Therapy Translational Medicine Research Centre, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Rong LiGuangdong Provincial Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.ORCID https://orcid.org/0000-0003-4951-577X
Jun ZhengOrgan Transplantation Research Center of Guangdong Province, Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Engineering Laboratory for Transplantation Medicine, Guangzhou, China.ORCID https://orcid.org/0000-0002-4283-0403
Funding
Academician Shusen Lanjuan Talent foundation (Yingcai Zhang, Jun Zheng), Liver Transplantation Program of People's Hospital of Xinjiang Uyghur Autonomous Region 20240101China Postdoctoral Science Foundation 2022M720176China Postdoctoral Science Foundation 2024t17107Guangdong Basic and Applied Basic Research Foundation 2021A1515111058Guangzhou Basic and Applied Basic Research Project Co-funded by Municipal Schools (institutes) 2023A03J0727Guangzhou Basic and Applied Basic Research Project Co-funded by Municipal Schools (institutes) 2023A1515010346Major talent project cultivation plan project of 3rd Affiliated Hospital of SYSU P02093National Natural Science Foundation of China 81802897National Natural Science Foundation of China 82270689National Natural Science Foundation of China 82300747National Natural Science Foundation of China 82303474National Natural Science Foundation of China 82400742National Natural Science Foundation of China 82470666Natural Science Foundation of Guangdong Province 2021A1515011156Natural Science Foundation of Guangdong Province 2021A1515012136Natural Science Foundation of Guangdong Province 2023A1515030052Natural Science Foundation of Guangdong Province 2024A1515011662Natural Science Foundation of Guangdong Province 2414050003502the National Key Research and Development Program of China 2022YFA1104903the National Key Research and Development Program of China 2024YFA1107200
Abstract
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) show powerful potential in the treatment of multiple diseases. However, the low yield of MSC-EVs severely restricts their clinical application. Here, heat shock (HS), a moderate external stimulus, can enhance EVs release of MSCs by upregulating autophagosome formation. Mechanistically, HS elevates TRPV2 expression to induce Ca
Indexed as
AutophagosomesExtracellular VesiclesHeat-Shock ResponseMesenchymal Stem Cells14-3-3 ProteinsAnimalsAutophagyAutophagy-Related Protein-1 HomologHumansLiverMaleMiceMice, Inbred C57BLReperfusion InjuryUp-Regulation14-3-3 ProteinsAutophagy-Related Protein-1 Homologextracellular vesicles releaseheat shockmesenchymal stem cellssuccinylation modificationTRPV2
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.