Evidence map›Paper›PMID 40326803›Full record

ReviewBalkan medical journal2025

Role and Significance of MicroRNAs in the Relationship Between Obesity and Cancer.

Ahmed S Doghish, Reda M Mansour, Sherif S Abdel Mageed, Hebatallah Ahmed Mohamed Moustafa, Osama A Mohammed, Ahmed E Elesawy, Nehal I Rizk

Abstract readReview
In one paragraph

Review in Balkan medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Systemic Molecular Alterations ofInternational journal of molecular sciences · 2026
    Article
  2. Review
  3. Review
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  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ahmed S DoghishDepartment of Biochemistry and Molecular Biology, Al-Azhar University Faculty of Pharmacy, Cairo, Egypt.ORCID 0000-0002-0136-7096
Reda M MansourDepartment of Zoology and Entomology, Helwan University Faculty of Science, Heiwan, Egypt.ORCID 0000-0002-5546-9020
Sherif S Abdel MageedDepartment of Pharmacology and Toxicology, Badr University in Cairo Faculty of Pharmacy, Cairo, Egypt.ORCID 0000-0003-0702-5035
Hebatallah Ahmed Mohamed MoustafaDepartment of Clinical Pharmacy and Pharmacy Practice, Badr University in Cairo Faculty of Pharmacy, Cairo, Egypt.ORCID 0000-0003-4530-406X
Osama A MohammedDepartment of Pharmacology, University of Bisha College of Medicine, Bisha, Saudi Arabia.ORCID 0000-0001-9712-9609
Ahmed E ElesawyDepartment of Biochemistry, Badr University in Cairo Faculty of Pharmacy, Cairo, Egypt.ORCID 0000-0002-3299-755X
Nehal I RizkDepartment of Biochemistry, Egyptian Chinese University Faculty of Pharmacy and Drug Technology, Cairo, Egypt.ORCID 0000-0002-9787-6003

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small, noncoding RNAs that are essential for regulating gene expression at the posttranscriptional stage. Recent research shows that miRNAs are crucial in the development of two major global health issues: obesity and cancer, two significant health issues worldwide. This study examines the complex mechanisms by which miRNAs govern vital biological processes, including adipogenesis, cancer, and metabolic dysregulation. We highlight the dual function of miRNAs as oncogenes and tumor suppressors in obesity-related malignancies and investigate their potential as prognostic and diagnostic markers. To demonstrate their varied roles, specific examples of vital miRNAs are underscored, such as miR-21, which promotes adipogenesis and is overexpressed in various cancers, and miR-34a, a tumor suppressor involved in cell cycle arrest and apoptosis. In addition, we examined the recent developments in miRNA-based therapies, which include miRNA inhibitors, mimics, and novel delivery vehicles and have the potential for treating obesity-related malignancies. This review aims to clarify, within the framework of miRNA biology, the therapeutic potential of miRNAs in addressing the interrelation between obesity and cancer.

Indexed as

MicroRNAsNeoplasmsObesityHumansMicroRNAs

Identifiers

PMID40326803
PMCPMC12060578

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.