Reprograming gene expression in 'hibernating'

Melanie Lianne Engelfriet, Yanwu Guo, Andreas Arnold, Eivind Valen, Rafal Ciosk

Abstract read

In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Melanie Lianne EngelfrietSection for Biochemistry and Molecular Biology, Department of Biosciences, University of Oslo, Oslo, Norway.ORCID https://orcid.org/0000-0002-0209-9492

Yanwu GuoSection for Biochemistry and Molecular Biology, Department of Biosciences, University of Oslo, Oslo, Norway.

Andreas ArnoldDivision of Molecular Neuroscience, Department of Biomedicine, University of Basel, Basel, Switzerland.

Eivind ValenSection for Biochemistry and Molecular Biology, Department of Biosciences, University of Oslo, Oslo, Norway.ORCID https://orcid.org/0000-0003-1840-6108

Rafal CioskSection for Biochemistry and Molecular Biology, Department of Biosciences, University of Oslo, Oslo, Norway.ORCID https://orcid.org/0000-0003-2234-6216

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026

$7.5M

NIH HHS Office of Research Infrastructure Programs P40 OD010440NIH HHS P40 OD010440The Norwegian Financial Mechanism 2014-2021 operated by the Polish National Science Center UMO-2019/34/H/NZ3/00691

6 · The paper itself

Abstract

In nature, many animals respond to cold by entering hibernation, while in clinical settings, controlled cooling is used in transplantation and emergency medicine. However, the molecular mechanisms that enable cells to survive severe cold are still not fully understood. One key aspect of cold adaptation is the global downregulation of protein synthesis. Studying it in the nematode

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsGene Expression RegulationHibernationProtein Serine-Threonine KinasesSignal TransductionAnimalsCarrier ProteinsCold TemperatureUnfolded Protein ResponseCaenorhabditis elegans ProteinsCarrier ProteinsIRE-1 protein, C elegansProtein Serine-Threonine KinasesXBP-1 protein, C elegansC. eleganscell biologycold dormancyER stressglobal translationhibernationhypothermiaUPR

Identifiers

PMID40326887

DOI10.7554/eLife.101186

PMCPMC12055002

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.