ArticleMolecular biology of the cell2025
The Erv41-Erv46 complex serves as a retrograde receptor to retrieve misfolded secretory proteins that have escaped from the ER.
Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- An integrated proximity labeling and vesicle reconstitution assay identifies novel regulators of Sonic hedgehog secretion.Molecular biology of the cell · 2026Article
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3 authors.
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Abstract
The Erv41-Erv46 complex is a conserved transmembrane cargo receptor that returns endoplasmic reticulum (ER)-resident proteins that have reached the Golgi complex back to the ER. Here, we report that this retrograde receptor also retrieves misfolded secretory cargo that contain luminal domain lesions, such as CPY*. Cells lacking Erv41-Erv46, increase the cellular clearance of misfolded cargo proteins due to increased ER escape and transport to the cell surface or to the vacuole for degradation. Erv41-Erv46 displays selectivity in binding misfolded substrates compared with their folded counterparts. Binding experiments reconstituted with purified proteins demonstrate that Erv41-Erv46 complex binds directly to misfolded CPY* through a shared cargo-binding site. These findings indicate that Erv41-Erv46 acts as a post-ER protein quality control checkpoint and expand the client range by which retrograde receptors ensure delivery of correctly folded secretory proteins.
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