Article in American journal of physiology. Endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors.
Ji Ho SuhDepartment of Anesthesiology, Critical Care and Pain Medicine and Center for Perioperative Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, United States.
Inyoung CheonDepartment of Anesthesiology, Critical Care and Pain Medicine and Center for Perioperative Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, United States.
Hyun-Jung JungDepartment of Anesthesiology, Critical Care and Pain Medicine and Center for Perioperative Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, United States.
Sung Ho LeeDepartment of Biomedical Laboratory Science, Gwangju Health University, Gwangju, South Korea.
Mi Jeong HeoDepartment of Anesthesiology, Critical Care and Pain Medicine and Center for Perioperative Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, United States.
Matthew DeBergeDepartment of Anesthesiology, Critical Care and Pain Medicine and Center for Perioperative Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, United States.
Clavia Ruth Wooton-KeeDepartment of Pediatrics-Nutrition, Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, United States.ORCID 0000-0003-4485-0747
Kang Ho KimDepartment of Anesthesiology, Critical Care and Pain Medicine and Center for Perioperative Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, United States.ORCID 0000-0003-2480-5308
Funding
THE ROLE OF HEPATOKINE ORM2 IN ADIPOSE TISSUE INFLAMMATIONR01DK126656 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KIM, KANGHO · 2021 to 2025
$1.9M
Nuclear Receptor Dysfunction Reprograms Metabolism and Cellular Proliferation in Wilson's DiseaseR01DK129579 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Clavia Ruth Wooton-Kee · 2022 to 2026
$1.6M
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK126656HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK129579Korea Health Industry Development Institute (KHIDI) RS-2023-00269801NIDDK NIH HHS R01 DK126656NIDDK NIH HHS R01 DK129579University of Texas Health Science Center at Houston (UTHealth) CPM Multi-PI Pilot AwardUSDA | Agricultural Research Service (ARS) 3092-51000-062-03SU.S. Department of Defense (DOD) W81XWH-18-1-0126
6 · The paper itself
Abstract
The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic nuclear receptors activated by various xenobiotics, drugs, hormones, and bile acids (BAs). Upon activation, these nuclear receptors play critical roles in regulating systemic energy homeostasis. However, precise mechanisms through which CAR and PXR influence systemic metabolism remain incompletely understood. Here, we investigated the impact of CAR and PXR on the liver-secreted hormone (i.e., hepatokine) expressions in response to BA stress, such as cholic acid (CA) feeding. Our analysis revealed that several BA-activated genes, including the well-known CAR/PXR target, aldo-keto reductase family 1, member B7 (
Indexed as
Bile Acids and SaltsLiverPregnane X ReceptorReceptors, Cytoplasmic and NuclearAnimalsCholic AcidConstitutive Androstane ReceptorGene Expression RegulationMaleMiceMice, Inbred C57BLXenobioticsBile Acids and SaltsCholic AcidConstitutive Androstane ReceptorPregnane X ReceptorReceptors, Cytoplasmic and NuclearXenobioticsbile acidconstitutive androstane receptororosomucoidpregnane X receptorsecretome
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.