Evidence map›Paper›PMID 40327542›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2026

Sustained Effectiveness of Doxycycline Post-Exposure-Prophylaxis in a Large Sexual Health Clinic Over 96 Weeks: An Interrupted Time Series Analysis.

Matthew A Spinelli, Megan J Heise, Jorge Roman, Jason Bena, Michael P Barry, Susan P Buchbinder, Hyman M Scott

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. The Urgency of Now: Congenital Syphilis in the Doxycycline Post-exposure Prophylaxis Era.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew A SpinelliDivision of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, California, USA.ORCID 0000-0001-6368-8664
Megan J HeiseDivision of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, California, USA.ORCID 0000-0001-6651-2381
Jorge RomanSan Francisco AIDS Foundation, San Francisco, California, USA.
Jason BenaSan Francisco AIDS Foundation, San Francisco, California, USA.
Michael P BarrySan Francisco AIDS Foundation, San Francisco, California, USA.ORCID 0000-0003-4878-1208
Susan P BuchbinderBridge HIV, San Francisco Department of Public Health, San Francisco, California, USA.ORCID 0000-0003-2404-0712
Hyman M ScottSan Francisco AIDS Foundation, San Francisco, California, USA.

Funding

Developing a U.S. National Cohort to Improve Virologic Suppression among Stimulant-using Men Living with HIV.UH3DA058304 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adam Wayne Carrico, Monica Gandhi · 2025 to 2026
$3.6M
Randomized Directly Observed Therapy Study to Interpret Clinical Trials of Doxy-PEPR01AI186641 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SPINELLI, MATTHEW A. · 2024 to 2025
$1.6M
NIAID NIH HHS R01 AI186641NIDA NIH HHS UH3 DA058304NIH HHS R01AI186641
6 · The paper itself

Abstract

Doxycycline post-exposure prophylaxis (doxy-PEP) reduced bacterial sexually transmitted infection (STI) incidence in a sexual health clinic over 96 weeks (N = 4592; 2524 on doxy-PEP), particularly for chlamydia and syphilis, with smaller effects for gonorrhea. Continued surveillance for gonorrhea and antibiotic resistance is essential to evaluate doxy-PEP's long-term effectiveness.

Indexed as

Anti-Bacterial AgentsDoxycyclinePost-Exposure ProphylaxisSexually Transmitted Diseases, BacterialAdultAmbulatory Care FacilitiesChlamydia InfectionsFemaleGonorrheaHumansIncidenceInterrupted Time Series AnalysisMaleSexual HealthSyphilisAnti-Bacterial AgentsDoxycyclineantibiotic prophylaxisdoxycyclinepost-exposure prophylaxissexual healthsexually transmitted infections

Identifiers

PMID40327542
PMCPMC13616491

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.