ReviewChemistry (Weinheim an der Bergstrasse, Germany)2025
Advances in Mechanochemical Methods for One-Pot Multistep Organic Synthesis.
Review in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Mechanochemical Integration of Incompatible Reaction Environments for the One-Pot Synthesis of Structurally Diverse N-Heterocycles.ChemSusChem · 2026Article
- Arenediazonium-generated aryl radical and nitrile coupling cascade under neat and catalyst-free conditions: green synthesis of anilides.RSC advances · 2026Article
- Machine learning-assisted development of a fast Mechanochemical Johnson-Corey-Chaykovsky reaction.Nature communications · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanochemical synthesis has emerged as a powerful and more sustainable alternative to conventional solution-based methods, offering advantages such as no or only minimal solvent use, reduced reaction times, and simplified operational conditions. The integration of multiple steps into a single reaction vessel further enhances these benefits by eliminating workup and purification steps, reducing waste, and often improving overall efficiency. This review highlights recent advancements in mechanochemical one-pot multistep reactions in organic synthesis, focusing on protocols with sequential one-pot operation. Diverse transformations are covered, including heterocycle formation, functional group interconversions, and the synthesis of active pharmaceutical ingredients, while discussing both the operational and environmental advantages of these methodologies, along with their remaining challenges. Overall, mechanochemical one-pot synthesis has the potential to streamline transformations and therefore contribute to more sustainable approaches in modern organic synthetic chemistry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.