Evidence map›Paper›PMID 40327688›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

METTL3 mediates atheroprone flow-induced glycolysis in endothelial cells.

Guo-Jun Zhao, So Yun Han, Yajuan Li, Dongqiang Yuan, Shuo Qin, Yuhan Li, Hongje Jang, Li-Jing Chen, Tong-You Wade Wei, Ming He and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. mFrontiers in cell and developmental biology · 2026
    Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Guo-Jun Zhao *Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
So Yun Han *Division of Cardiology, Department of Medicine, University of California, La Jolla, CA 92093.
Yajuan LiDepartment of Bioengineering, University of California at San Diego, La Jolla, CA 92093.
Dongqiang YuanDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010.
Shuo QinDepartment of Bioengineering, University of California at San Diego, La Jolla, CA 92093.
Yuhan LiDepartment of Bioengineering, University of California at San Diego, La Jolla, CA 92093.
Hongje JangDepartment of Bioengineering, University of California at San Diego, La Jolla, CA 92093.
Li-Jing ChenInstitute of Engineering in Medicine, University of California, La Jolla, CA 92093.
Tong-You Wade WeiDivision of Cardiology, Department of Medicine, University of California, La Jolla, CA 92093.
Ming HeDivision of Cardiology, Department of Medicine, University of California, La Jolla, CA 92093.
Yi-Shun LiDepartment of Bioengineering, University of California at San Diego, La Jolla, CA 92093.
Zhen Bouman ChenDepartment of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope, Duarte, CA 91010.
Lingyan ShiDepartment of Bioengineering, University of California at San Diego, La Jolla, CA 92093.
Shu ChienDepartment of Bioengineering, University of California at San Diego, La Jolla, CA 92093.ORCID 0000-0003-0332-285X
John Y-J ShyyDivision of Cardiology, Department of Medicine, University of California, La Jolla, CA 92093.

Funding

Role of Spatiotemporal Epigenetic Dynamics in Regulating Endothelial Gene Expressions under FlowsR01HL121365 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · 2021 to 2025
$1.7M
Shear stress Regulation of Endothelial Glycolysis via METTL3-mediated RNA m6A ModificationR01HL170107 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2025 to 2025
$826k
RNA-mediated endotheliopathy in diabetic vasculopathyR35HL171550 · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · 2025 to 2025
$814k
AMPK Regulation of ACE2 in Endothelial Health and DiseaseR01HL162302 · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2025 to 2025
$657k
National Institutes of Health National Heart, Lung and Blood Institute R35HL171550 R01HL121365 HL108735 HL170107National Natural Science Foundation of China 82100283NHLBI NIH HHS R01 HL108735NHLBI NIH HHS R01 HL121365NHLBI NIH HHS R01 HL162302NHLBI NIH HHS R01 HL170107NHLBI NIH HHS R35 HL171550
6 · The paper itself

Abstract

Atheroprone flow-increased glycolysis in vascular endothelial cells (ECs) is pivotal in EC dysfunction and the initiation of atherosclerosis. Methyltransferase 3 (METTL3) is a major m

Indexed as

AtherosclerosisEndothelial CellsGlycolysisMethyltransferasesAnimalsHexokinaseHumansHuman Umbilical Vein Endothelial CellsMaleMiceMice, Inbred C57BLPhosphofructokinase-2HexokinaseMethyltransferasesMETTL3 protein, humanMettl3 protein, mousePFKFB3 protein, humanPhosphofructokinase-2atherosclerosisendothelial cellglycolysisshear stress

Identifiers

PMID40327688
PMCPMC12088407

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.