Evidence map›Paper›PMID 40328737›Full record

ArticleNature communications2025

HiBC: a publicly available collection of bacterial strains isolated from the human gut.

Thomas C A Hitch, Johannes M Masson, Charlie Pauvert, Johanna Bosch, Selina Nüchtern, Nicole S Treichel, Marko Baloh, Soheila Razavi, Afrizal Afrizal, Ntana Kousetzi and 34 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Review
  3. Genomic characterization ofMicrobiology spectrum · 2026
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  5. NovelGut · 2026
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  6. Article
  7. Article
  8. Article
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  10. High-throughput single-cell isolation ofMicrobiology spectrum · 2026
    Article
  11. Article
  12. Proposal of two novel species,International journal of systematic and evolutionary microbiology · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Thomas C A HitchFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.ORCID http://orcid.org/0000-0003-2244-7412
Johannes M Masson *Functional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.
Charlie Pauvert *Functional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.ORCID http://orcid.org/0000-0001-9832-2507
Johanna BoschFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.ORCID http://orcid.org/0000-0003-3982-849X
Selina NüchternFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.
Nicole S TreichelFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.ORCID http://orcid.org/0009-0008-2472-5061
Marko BalohFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.
Soheila RazaviFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.
Afrizal AfrizalFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.
Ntana KousetziFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.
Andrea M AguirreFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.
David WylensekFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.ORCID http://orcid.org/0000-0002-8424-5712
Amy C CoatesFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.ORCID http://orcid.org/0009-0007-9234-5725
Susan A V JenningsFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.
Atscharah PanyotFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.
Alina ViehofFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.ORCID http://orcid.org/0000-0001-9873-3170
Matthias A SchmitzFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.ORCID http://orcid.org/0009-0008-4418-4012
Maximilian StuhrmannFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.
Evelyn C DeisFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.
Kevin BisdorfFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.
Maria D ChiotelliBiophysics of Host-Microbe Interactions Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.ORCID http://orcid.org/0000-0001-5975-7989
Artur LissinLeibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.ORCID http://orcid.org/0009-0007-3729-1533
Isabel SchoberLeibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.ORCID http://orcid.org/0000-0002-4894-1913
Julius WitteLeibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.ORCID http://orcid.org/0009-0005-9790-9097
Thorsten CramerMolecular Tumor Biology Research Group, Department of General, Visceral, Children and Transplantation Surgery, University Hospital of RWTH Aachen, Aachen, Germany.ORCID http://orcid.org/0000-0002-6462-239X
Thomas RiedelLeibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.
Marie WendeDepartment of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Katrin A WinterDepartment of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.ORCID http://orcid.org/0009-0005-4180-0244
Lena AmendDepartment of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany.ORCID http://orcid.org/0000-0002-5066-7140
Alessandra RivaCenter for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystem Science, University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-5724-7616
Stefanie TrinhInstitute of Neuroanatomy, University Hospital of RWTH Aachen, Aachen, Germany.
Laura MitchellSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Jonathan HartmanIT centre, RWTH Aachen University, Aachen, Germany.ORCID http://orcid.org/0009-0000-2792-106X
David BerryCenter for Microbiology and Environmental Systems Science, Department of Microbiology and Ecosystem Science, University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-8997-608X
Jochen SeitzClinic for Child and Adolescent Psychiatry, Psychosomatic Medicine and Psychotherapy, LVR-University Hospital Essen, University of Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0002-0110-7980
Lukas C BossertIT centre, RWTH Aachen University, Aachen, Germany.
Marianne GrognotBiophysics of Host-Microbe Interactions Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany.ORCID http://orcid.org/0000-0002-7491-1224
Thorsten AllersSchool of Life Sciences, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-7308-3332
Till StrowigGerman Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Braunschweig, Germany.ORCID http://orcid.org/0000-0003-0185-1459
Michael PesterLeibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.ORCID http://orcid.org/0000-0001-6296-4145
Birte AbtLeibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.
Lorenz C ReimerLeibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.
Jörg OvermannLeibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.ORCID http://orcid.org/0000-0003-3909-7201
Thomas ClavelFunctional Microbiome Research Group, Institute of Medical Microbiology, University Hospital of RWTH Aachen, Aachen, Germany. tclavel@ukaachen.de.ORCID http://orcid.org/0000-0002-7229-5595

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 395357507Deutsche Forschungsgemeinschaft (German Research Foundation) 403224013Deutsche Forschungsgemeinschaft (German Research Foundation) 445552570Deutsche Forschungsgemeinschaft (German Research Foundation) 460129525Deutsche Forschungsgemeinschaft (German Research Foundation) 513892404
6 · The paper itself

Abstract

Numerous bacteria in the human gut microbiome remain unknown and/or have yet to be cultured. While collections of human gut bacteria have been published, few strains are accessible to the scientific community. We have therefore created a publicly available collection of bacterial strains isolated from the human gut. The Human intestinal Bacteria Collection (HiBC) ( https://www.hibc.rwth-aachen.de ) contains 340 strains representing 198 species within 29 families and 7 phyla, of which 29 previously unknown species are taxonomically described and named. These included two butyrate-producing species of Faecalibacterium and new dominant species associated with health and inflammatory bowel disease, Ruminococcoides intestinale and Blautia intestinihominis, respectively. Plasmids were prolific within the HiBC isolates, with almost half (46%) of strains containing plasmids, with a maximum of six within a strain. This included a broadly occurring plasmid (pBAC) that exists in three diverse forms across Bacteroidales species. Megaplasmids were identified within two strains, the pMMCAT megaplasmid is globally present within multiple Bacteroidales species. This collection of easily searchable and publicly available gut bacterial isolates will facilitate functional studies of the gut microbiome.

Indexed as

BacteriaGastrointestinal MicrobiomeFecesHumansPhylogenyPlasmids

Identifiers

PMID40328737
PMCPMC12056005

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.