ArticleScientific data2025
Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI.
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28citing papers in PubMed
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28 citing papers in PubMed.
- Charting confidence in white matter brain charts: enabling study planning through stability validation.Journal of medical imaging (Bellingham, Wash.) · 2026Article
- Regional Brain Volume Variation Across Adulthood: A Cross-Sectional MRI Analysis of Age, Sex, and Hemispheric Asymmetry.Life (Basel, Switzerland) · 2026Article
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- Comparing Harmonization Approaches for Protocol-Related Variability in Multisite Diffusion MRI Data.bioRxiv : the preprint server for biology · 2026Article
- Article
- ComBat-Predict Enhances Generalizability of Neuroimaging Models to New Sites.Human brain mapping · 2026Article
- Lifespan Trajectories of Asymmetry in White Matter Tracts.Human brain mapping · 2026Article
- Harmonization in magnetic resonance imaging: A survey of acquisition, image-level, and feature-level methods.Medical image analysis · 2026Review
- Open diffusion magnetic resonance imaging and connectivity data for epilepsy and surgery: The IDEAS II release.Epilepsia · 2026Article
- Connectome-based spatial statistics enabling large-scale population analyses of human connectome across cohorts.bioRxiv : the preprint server for biology · 2026Article
- Leveraging Longitudinal Data to Improve BrainChart Calibration for Small Study Sample Sizes.Human brain mapping · 2026Article
- Ultra-fast MRI for brain-age prediction in a real-world cognitive disorders clinic.Frontiers in aging neuroscience · 2026Article
- Calibration of MRI-based reference intervals to new samples.bioRxiv : the preprint server for biology · 2025Article
- Lifespan Normative Modeling of Brain Microstructure.bioRxiv : the preprint server for biology · 2025Article
- Cross-site harmonization of diffusion MRI data without matched training subjects.Magnetic resonance in medicine · 2025Article
- White matter microstructure changes across the lifespan: a meta-analysis of longitudinal diffusion MRI studies.bioRxiv : the preprint server for biology · 2025Article
- ComBatLS: A Location- and Scale-Preserving Method for Multi-Site Image Harmonization.Human brain mapping · 2025Article
- White matter microstructure and macrostructure brain charts across the human lifespan.bioRxiv : the preprint server for biology · 2025Article
- Evidence for white matter intrinsic connectivity networks at rest and during a task: A large-scale study and templates.Network neuroscience (Cambridge, Mass.) · 2025Article
- When no answer is better than a wrong answer: A causal perspective on batch effects.Imaging neuroscience (Cambridge, Mass.) · 2025Article
Corrections and comments
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Authors and funding
17 authors.
Alyssa H ZhuImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Talia M NirImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Shayan JavidImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.ORCID http://orcid.org/0009-0000-8538-2420
Julio E Villalón-ReinaImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Amanda L RodrigueDepartment of Psychiatry and Behavioral Science, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Lachlan T StrikeQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Greig I de ZubicarayQueensland University of Technology, Brisbane, QLD, Australia.
Katie L McMahonQueensland University of Technology, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0002-6357-615X
Margaret J WrightQueensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0001-7133-4970
Sarah E MedlandQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-1382-380X
John BlangeroDepartment of Human Genetics, University of Texas Rio Grande Valley, Brownsville, TX, USA.ORCID http://orcid.org/0000-0001-6250-5723
David C GlahnDepartment of Psychiatry and Behavioral Science, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Peter KochunovFaillace Department of Psychiatry and Behavioral Sciences at McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Douglas E WilliamsonDepartment of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.
Asta K HåbergDepartment of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Paul M ThompsonImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.
Neda JahanshadImaging Genetics Center, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA. njahansh@usc.edu.ORCID http://orcid.org/0000-0003-4401-8950
Funding
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MSmartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5MABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7MABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5MThe natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MMapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7MAdolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5MNeuroimaging CoreU19AG076581 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GABRIEL Alejandro DE ERAUSQUIN, Gabriela Gonzalez_Aleman · 2023 to 2026
$32.9MABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7MProspective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2MAlzheimer's Association ZenithDepartment of Health | National Health and Medical Research Council (NHMRC) 1009064Department of Health | National Health and Medical Research Council (NHMRC) 496682NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NHGRI NIH HHS U54 HG013247NIAAA NIH HHS R01 AA016274NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG059305NIA NIH HHS P30 AG066444NIA NIH HHS R01 AG043434NIA NIH HHS R01 AG058464NIA NIH HHS R01 AG058854NIA NIH HHS R01 AG059874NIA NIH HHS R01 AG078423NIA NIH HHS R01 AG087513NIA NIH HHS RF1 AG057892NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG076581NIBIB NIH HHS P41 EB015922NIBIB NIH HHS R01 EB009352NIBIB NIH HHS R01 EB015611NICHD NIH HHS N01 HD023343NICHD NIH HHS R01 HD050735NIDA NIH HHS RC2 DA029475NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050987NIDA NIH HHS U01 DA050988NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051016NIDA NIH HHS U01 DA051018NIDA NIH HHS U01 DA051037NIDA NIH HHS U01 DA051038NIDA NIH HHS U01 DA051039NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIMH NIH HHS R01 MH078111NIMH NIH HHS R01 MH083824NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH134004NIMH NIH HHS RF1 MH123163NIMH NIH HHS U01 MH109589NIMH NIH HHS U54 MH091657NINDS NIH HHS RF1 NS136995U.S. Department of Health & Human Services | National Institutes of Health (NIH) P30AG059305U.S. Department of Health & Human Services | National Institutes of Health (NIH) P41EB015922U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AA016274U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AG058464U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AG058854U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AG078423U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01MH116147U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01MH134004U.S. Department of Health & Human Services | National Institutes of Health (NIH) RF1AG057892U.S. Department of Health & Human Services | National Institutes of Health (NIH) U19AG076581U.S. Department of Health & Human Services | National Institutes of Health (NIH) U54HG013247U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH0708143U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH078111U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH083824Wellcome Trust
Abstract
Age-related white matter (WM) microstructure maturation and decline occur throughout the human lifespan, complementing the process of gray matter development and degeneration. Here, we create normative lifespan reference curves for global and regional WM microstructure by harmonizing diffusion MRI (dMRI)-derived data from ten public datasets (N = 40,898 subjects; age: 3-95 years; 47.6% male). We tested three harmonization methods on regional diffusion tensor imaging (DTI) based fractional anisotropy (FA), a metric of WM microstructure, extracted using the ENIGMA-DTI pipeline. ComBat-GAM harmonization provided multi-study trajectories most consistent with known WM maturation peaks. Lifespan FA reference curves were validated with test-retest data and used to assess the effect of the ApoE4 risk factor for dementia in WM across the lifespan. We found significant associations between ApoE4 and FA in WM regions associated with neurodegenerative disease even in healthy individuals across the lifespan, with regional age-by-genotype interactions. Our lifespan reference curves and tools to harmonize new dMRI data to the curves are publicly available as eHarmonize ( https://github.com/ahzhu/eharmonize ).
Indexed as
BrainDiffusion Magnetic Resonance ImagingLongevityWhite MatterAdolescentAdultAgedAged, 80 and overApolipoprotein E4ChildChild, PreschoolDiffusion Tensor ImagingFemaleHumansMaleMiddle AgedApolipoprotein E4
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.