ArticleScientific reports2025
The mechanism of miR-155 targeting PIK3R1 in the pathogenesis of preeclampsia.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Understanding Preeclampsia: Integrating Placental Dysfunction, Immune Dysregulation and microRNA-Mediated Epigenetic Regulation.International journal of molecular sciences · 2026Review
- microRNA-155: a versatile noncoding RNA.Molecular biology reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
To explore the molecular mechanism of miRNA-155-5p regulating placental trophoblast cell function and affecting preeclampsia. RNA was measured via RT-qPCR, and protein was detected with Western blot as well as Immunohistochemistry. Cell viability, proliferation, migration as well as invasion were detected via CCK8 assay, EDU stain as well as Transwell. Tunel assay measures cell apoptosis. Dual-Luciferase Reporter Assay affirms targeting relationships of miRNA-155-5p and PIK3R1. MiR-155-5p in PE patients' placental trophoblasts was markedly higher, while PIK3R1 was lower. Knockdown of miR-155-5p in trophoblast enhanced cell viability, proliferation, migration as well as invasion, while reducing apoptosis. The predicted target gene of miR-155-5p was PIK3R1, while PIK3R1 expression was inversely correlated to miR-155-5p in HTR-8/SVneo. In trophoblast overexpressing miR-155-5p, increased PIK3R1 expression could reverse the effect. We confirmed that miR-155-5p affects the function of placental trophoblast HTR-8/SVneo, and confirmed that miR-155-5p affects the development of PE by regulating PIK3R1, which provides a target for treatment as well as prevention of PE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.