ArticleNaunyn-Schmiedeberg's archives of pharmacology2025
L-theanine prevents myocardial injury in sleep‑deprived mice by suppressing ferroptosis through SIRT1.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Green tea is obtained from Camellia sinensis, and its role in promoting heart health has been widely recognized in traditional Chinese medicine. L-theanine, one of the main bioactive components of green tea, has antioxidant and cardiovascular protective effects. However, the effects of L-theanine on myocardial cells in sleep-deprived mice and its potential mechanisms have not been clearly elucidated. This study utilized a modified multiple-platform water environment method to establish an SD model and induce a ferroptosis model in H9c2 cells pretreated with erastin. The cardiac function parameters of mice were assessed using a small animal super-resolution ultrasound imaging system. H&E staining was used to evaluate pathological changes in tissue structure and cell morphology, while transmission electron microscopy (TEM) was employed to observe the extent of mitochondrial damage. Biochemical assays were employed to quantify myocardial damage markers, oxidative stress indicators, and Fe
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