Evidence map›Paper›PMID 40328948›Full record

ArticleScientific reports2025

Association between salivary immune markers and oral health conditions in pregnant women.

Nora Alomeir, Xinyue Mao, Ruqian Yang, Nasser Assery, Sally Quataert, Antti Seppo, Xingyi Lu, Tong Tong Wu, Jin Xiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Nora AlomeirEastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, 14620, USA.
Xinyue MaoBiostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, 14620, USA.
Ruqian YangEastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, 14620, USA.
Nasser AsseryEastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, 14620, USA.
Sally QuataertImmunology and Microbiology, University of Rochester Medical Center, Rochester, NY, 14620, USA.
Antti SeppoDepartment of Pediatrics, University of Rochester Medical Center, Rochester, NY, 14620, USA.
Xingyi LuEastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, 14620, USA.
Tong Tong WuBiostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, 14620, USA.
Jin XiaoEastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, 14620, USA. jin_xiao@urmc.rochester.edu.

Funding

Understand biological factors underlying early childhood caries disparity from the oral microbiome in early infancyR01DE031025 · NIDCR · UNIVERSITY OF ROCHESTER · 2024 to 2025
$1.4M
NIDCR NIH HHS R01 DE031025the National Institutes of Health R01DE031025
6 · The paper itself

Abstract

This study aims to assess levels of salivary immune markers in women during the 3rd trimester of pregnancy and explores the association between immune markers and dental caries, as well as oral carriage of oral pathogens Candida albicans and Streptococcus mutans. These organisms are known to be associated with oral infectious diseases such as dental caries and oral candida infection. Methods: Pregnant women from underserved background participated in this study (n = 181). Participants received a comprehensive oral examination by trained and calibrated dentists. Levels of 36 immune markers in unstimulated saliva samples were measured using Bio-Plex200 (Luminex). Salivary S. mutans and C. albicans were quantified using viable count (CFU/ml). Quantities of immune markers and colony-forming-units of S. mutans and C. albicans were converted to natural log data for statistical analysis. Latent class analysis was used to assess the clustering effect of immune markers among the participants. Results: The study found high quantities of salivary immune markers in pregnant women with varying detection rates. Univariate analysis found a higher salivary level of IFN-g and TNF-b among women with < 4 decayed teeth, compared to those with ≥ 4 decayed teeth (p < 0.05). Among women with more than 10

Indexed as

Dental CariesOral HealthSalivaAdultBiomarkersCandida albicansFemaleHumansPregnancyStreptococcus mutansYoung AdultBiomarkersCandida albicansCandidiasisCariesImmunityPregnancyStreptococcus mutans

Identifiers

PMID40328948
PMCPMC12056013

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.