Evidence map›Paper›PMID 40329191›Full record

ArticleBMC infectious diseases2025

Genomic insights into the spread of methicillin-resistant Staphylococcus aureus involved in ear infections.

Zhewei Sun, Jinhong Chen, Chunhong Liu, Yueru Tian, Fuqi Ai, Jiaying Du, Wangxiao Zhou, Wenjun Cao, Ming Guan, Baixing Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhewei Sun *Department of Laboratory Medicine, Shanghai Medical College, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jinhong Chen *Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, 200040, China.
Chunhong Liu *Department of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China.
Yueru TianDepartment of Laboratory Medicine, Shanghai Medical College, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Fuqi AiDepartment of Laboratory Medicine, Shanghai Medical College, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jiaying DuDepartment of Laboratory Medicine, Shanghai Medical College, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Wangxiao ZhouClinical Laboratory Center, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Wenjun CaoDepartment of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, 200040, China. wgkjyk@aliyun.co.
Ming GuanDepartment of Laboratory Medicine, Shanghai Medical College, Huashan Hospital, Fudan University, Shanghai, 200040, China. guanming@shmu.edu.cn.
Baixing DingInstitute of Antibiotics, Shanghai Medical College, Huashan Hospital, Fudan University, Shanghai, 20040, China. dingbaixing@163.com.

Funding

National Natural Science Foundation of China 81902103Science and Technology Commission of Shanghai Municipality 19JC1413002the Natural Science Foundation of Zhejiang Province LQN25H200008
6 · The paper itself

Abstract

backgroundMethicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen causing ear infections. However, genomic epidemiology and determinants influencing transmission of ear infections associated MRSA (EIA-MRSA) in community remain unknown.

methodsIn 2020-2021, 105 EIA-MRSA isolates were collected and sequenced from outpatients across different households in Shanghai, China. Antimicrobial susceptibility testing, core genome MLST, and phylodynamic analyses were conducted to characterize EIA-MRSA dissemination.

resultsQuinolone resistance was identified as a risk factor for EIA-MRSA spread (OR 9, [95% CI 3-31]). The ST764 clone and two subclones of ST22-PT hypervirulent clone have developed an extensive quinolone-resistant (eQR) phenotype, conferring additional resistance to advanced quinolones due to the accumulation of four mutations in gyrA (S84L and either S85P, E88K, or E88G) and parC (S80F and either E84K or E84G). These ST764- and ST22-PT-eQR isolates were highly transmissible and showed increased resistance to other commonly used antimicrobials, posing potential high-risk clones. The eQR phenotype may be inherent to the ST764 lineage, which emerged in the late 1980s, coinciding with the widespread fluoroquinolone usage. The ST22-PT-eQR subclones emerged in around 2017 and are accumulating resistance genes.

conclusionVigilance is crucial for eQR high-risk clones, particularly the convergent ST22-PT-eQR subclones that accumulate resistance and virulence traits, posing risks for ear infections. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Methicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsAdultAnti-Bacterial AgentsChildChinaFemaleGenome, BacterialGenomicsHumansMaleMicrobial Sensitivity TestsMiddle AgedMultilocus Sequence TypingQuinolonesAnti-Bacterial AgentsQuinolonesAntimicrobial resistanceEar infectionsMethicillin-resistant staphylococcus aureusTransmissionWhole genome sequencing

Identifiers

PMID40329191
PMCPMC12054198

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.