Evidence map›Paper›PMID 40329215›Full record

ArticleBMC infectious diseases2025

Prevalence and predictors of unsuccessful tuberculosis treatment outcomes among persons with TB/HIV co-infection in Ghana: a 10-year retrospective study.

Alhaji Ibrahim Cobbinah, Jacob Solomon Idan, Kingsley Boakye, Anthony Enimil, Nicholas Karikari Mensah, Ebenezer Adangabe, Sulemana Baba Abdulai, Charles Martyn-Dickens, Aliyu Mohammed

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Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alhaji Ibrahim CobbinahDepartment of Epidemiology and Biostatistics, School of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Cobbinahalhaji@gmail.com.ORCID http://orcid.org/0009-0005-3360-5000
Jacob Solomon IdanDepartment of Epidemiology and Biostatistics, School of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Kingsley BoakyeDepartment of Epidemiology and Biostatistics, School of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Anthony EnimilDirectorate of Child Health, Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana.
Nicholas Karikari MensahDepartment of Epidemiology and Biostatistics, School of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Ebenezer AdangabeDepartment of Epidemiology and Biostatistics, School of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Sulemana Baba AbdulaiDepartment of Epidemiology and Biostatistics, School of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Charles Martyn-DickensDirectorate of Child Health, Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana.
Aliyu MohammedDepartment of Epidemiology and Biostatistics, School of Public Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionUnsuccessful treatment outcomes significantly impact tuberculosis control efforts globally particularly among individuals co-infected with Human Immunodeficiency Virus (HIV). This study aimed to assess the prevalence, trends, and associated factors of unsuccessful Tuberculosis (TB) treatment outcomes among persons with TB/HIV co-infection at Komfo Anokye Teaching Hospital in Ghana over a 10-year period.

methodsA retrospective cross-sectional study was conducted using data from the Komfo Anokye Teaching Hospital between January 2012 and December 2022. A total of 1,242 persons with TB/HIV co-infection were included in the study. Unsuccessful treatment outcomes were defined as death, treatment failure, or default. Modified Poisson regression with robust standard errors was performed using Stata version 17.0 to identify predictors of unsuccessful outcomes. Crude and adjusted relative risk ratios with 95% confidence intervals (CI) were reported, and a p-value < 0.05 was considered statistically significant.

resultsThe prevalence of unsuccessful treatment outcomes for the 10-year period was 24.6% (95% CI: 22.3-27.1). The analysis revealed a decreasing trend of unsuccessful TB treatment outcomes from 47.6% in 2012 to 7.79 in 2022. In the multivariable analysis, older age (≥ 65 years) was associated with a higher risk of unsuccessful outcomes (ARR: 5.6, 95% CI: 2.8-11.1). Conversely, pretreatment weights of 40-54 kg (ARR: 0.5, 95% CI: 0.3-0.7), 55-69 kg (ARR: 0.4, 95% CI: 0.3-0.6), and ≥ 74 kg (ARR: 0.2, 95% CI: 0.1-0.7) were associated with reduced risk. The presence of a treatment supporter also lowered the risk of unsuccessful outcomes (ARR: 0.8, 95% CI: 0.6-0.9).

conclusionThe high prevalence of unsuccessful TB treatment outcomes among persons with TB/HIV co-infection within the 10-year period highlights the need for targeted interventions. Prioritizing care for older patients, improving nutritional support, and promoting treatment supporter involvement will enhance treatment success in Ghana. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Antitubercular AgentsCoinfectionHIV InfectionsTuberculosisAdolescentAdultAgedCross-Sectional StudiesFemaleGhanaHumansMaleMiddle AgedPrevalenceRetrospective StudiesRisk FactorsAntitubercular AgentsCo-infectionGhanaHIVPredictorsTreatment outcomesTuberculosis

Identifiers

PMID40329215
PMCPMC12057233

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.