ArticleThe British journal of psychiatry : the journal of mental science2026
Changes in brain function during negative emotion processing following cognitive-behavioural therapy in depressive disorders.
Article in The British journal of psychiatry : the journal of mental science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Randomized target engagement trial of a dissonance-based transdiagnostic eating disorder treatment versus transdiagnostic interpersonal psychotherapy.Psychological medicine · 2025Trial
- Longitudinal associations between white matter integrity, early life adversities, and treatment response following cognitive-behavioral therapy in depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
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Authors and funding
15 authors.
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Abstract
backgroundCognitive-behavioural therapy (CBT) is a first-line treatment for depressive disorders, but research on its neurobiological mechanisms is limited. Given the heterogeneity in CBT response, investigating the neurobiological effects of CBT may improve response prediction and outcomes.
aimsTo examine brain functional changes during negative emotion processing following naturalistic CBT.
methodIn this case-control study, 59 patients with depressive disorders were investigated before and after 20 CBT sessions using a negative-emotion-processing paradigm during functional magnetic resonance imaging, clinical interviews and depressive symptom questionnaires. Healthy controls (
resultsAnalyses yielded a significant group × time interaction in the hippocampus (
conclusionsFollowing CBT, reduced activity in emotion-processing regions was observed in patients with depressive disorders, with hippocampal activity decreases linked to treatment response. This suggests successful CBT could correct biased emotion processing, potentially by altering activity in key areas of emotion processing. Hippocampal activity may function as a predictive marker of CBT response.
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