ArticleNational science review2025
Integrating large-scale meta-GWAS and PigGTEx resources to decipher the genetic basis of 232 complex traits in pigs.
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Article in National science review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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26citing papers in PubMed, 2 pooled it
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Integrated genome-wide association studies, meta-analysis, and Bayesian fine mapping reveal novel quantitative trait loci's and functional candidate genes for vulva traits in large white pigs.Journal of animal science · 2025Pooled it
- Genome-Wide Association Study of Rib Number and Total Thoracolumbar Vertebrae Number in a Jishen Black Pig Population.Veterinary sciences · 2026Article
- Multi-Omics Integration Identifies ABCD4 as a Key Regulator of Backfat Thickness and Lipid Deposition in Pietrain Pigs.Animal genetics · 2026Article
- Pig Matrix: a matched multiomics 3D regulatory genomics database for evolutionary and comparative analyses in pigs.Molecular biology and evolution · 2026Article
- Integrated GWAS and eQTL Colocalization Identified Candidate Genes for Growth Traits in Pigs.Biology · 2026Article
- Insights from adaptive immune regulation for disease resistance breeding in livestock and poultry.Science China. Life sciences · 2026Review
- Integrative multi-omics analysis identifies GNAZ and SLC5A4 as critical regulators of gestation length in Large White pigs.Genetics, selection, evolution : GSE · 2026Article
- Article
- Multi-Omics Analysis Reveals Age-Related Enhancements in Gut Morphology, Microbiome, and Metabolism of Tibetan Pigs.Microorganisms · 2026Article
- Role ofZoological research · 2026Article
- Causal variants in animal genomes: approaches to identification, phenotypic impact, and implications for selective breeding.BMC genomics · 2026Review
- Integrating GWAS and eQTL analysis to decipher genetic mechanisms of feed efficiency and feeding behaviors in pigs.Genetics, selection, evolution : GSE · 2026Article
- Characterizing breed-shared and breed-specific genetic regulatory effects of gene expression across three pig breeds.Journal of animal science and biotechnology · 2026Article
- Mendelian randomization and colocalization reveal potential causal effects of average daily gain on carcass composition and reproductive traits in pigs.Journal of animal science and biotechnology · 2026Article
- Review
- Multi-Tissue Genetic Regulation of RNA Editing in Pigs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Genomic Signatures Underlying Environmental Adaptation and Reproductive Traits in the Tibetan Pig.Animals : an open access journal from MDPI · 2026Article
- Identifying pleiotropic genes for backfat thickness and semen traits in pigs using GWAS summary data.Journal of animal science · 2026Article
- IPGCA: A Comprehensive Single Cell Atlas of 1 074 127 Porcine Intestinal Cells Revealing Cellular Dynamics, Genetic Regulation, and Cross-Species Conservation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
72 authors.
Zhiting XuState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.ORCID https://orcid.org/0000-0001-8830-3580
Qing LinState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.ORCID https://orcid.org/0000-0002-8416-9748
Xiaodian CaiState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Zhanming ZhongState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Jinyan TengState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Bingjie LiDepartment of Animal and Veterinary Sciences, The Roslin Institute Building, Scotland's Rural College (SRUC), Easter Bush, Midlothian EH25 9RG, UK.ORCID https://orcid.org/0000-0002-8528-1889
Haonan ZengState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Yahui GaoState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Zexi CaiCenter for Quantitative Genetics and Genomics (QGG), Aarhus University, Aarhus 8000, Denmark.ORCID https://orcid.org/0000-0002-9579-3415
Xiaoqing WangInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Liangyu ShiInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Xue WangCollege of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Yi WangCollege of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Zipeng ZhangCollege of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Yu LinKey Laboratory of Agricultural Bioinformatics, Ministry of Education, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Shuli LiuWestlake Laboratory of Life Sciences and Biomedicine, Hangzhou 310024, China.ORCID https://orcid.org/0009-0006-8379-4994
Hongwei YinShenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, China.
Zhonghao BaiCenter for Quantitative Genetics and Genomics (QGG), Aarhus University, Aarhus 8000, Denmark.
Chen WeiState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Jun ZhouState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Wenjing ZhangState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Xiaoke ZhangState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.ORCID https://orcid.org/0000-0001-6961-9475
Shaolei ShiState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Jun WuState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.ORCID https://orcid.org/0000-0001-5537-6804
Shuqi DiaoState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Yuqiang LiuState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Xiangchun PanState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Xueyan FengState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Ruiqi LiuState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Zhanqin SuState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Chengjie ChangState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Qianghui ZhuState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Yuwei WuState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Zhongyin ZhouState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Lijing BaiShenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, China.
Kui LiShenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, China.
Qishan WangDepartment of Animal Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.ORCID https://orcid.org/0000-0002-6475-0009
Yuchun PanDepartment of Animal Science, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China.ORCID https://orcid.org/0000-0002-1163-5963
Zhong XuHubei Key Laboratory of Animal Embryo and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Provincial Academy of Agricultural Sciences, Wuhan 430064, China.
Xianwen PengHubei Key Laboratory of Animal Embryo and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Provincial Academy of Agricultural Sciences, Wuhan 430064, China.
Shuqi MeiHubei Key Laboratory of Animal Embryo and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Provincial Academy of Agricultural Sciences, Wuhan 430064, China.
Delin MoState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.ORCID https://orcid.org/0000-0002-8738-4486
Xiaohong LiuState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Hao ZhangState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Xiaolong YuanState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.ORCID https://orcid.org/0000-0002-3743-0130
Yang LiuCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
George E LiuAnimal Genomics and Improvement Laboratory, Henry A. Wallace Beltsville Agricultural Research Center, Agricultural Research Service (ARS), U.S.Department of Agriculture (USDA), Beltsville, Maryland 20705, USA.
Guosheng SuCenter for Quantitative Genetics and Genomics (QGG), Aarhus University, Aarhus 8000, Denmark.
Goutam SahanaCenter for Quantitative Genetics and Genomics (QGG), Aarhus University, Aarhus 8000, Denmark.
Mogens Sandø LundCenter for Quantitative Genetics and Genomics (QGG), Aarhus University, Aarhus 8000, Denmark.
Li MaDepartment of Animal and Avian Sciences, University of Maryland, College Park, Maryland 20742, USA.
Ruidong XiangFaculty of Veterinary & Agricultural Science, University of Melbourne, Parkville, VIC 3010, Australia.
Xia ShenState Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China.ORCID https://orcid.org/0000-0003-4390-1979
Pinghua LiInstitute of Swine Science, Nanjing Agricultural University, Nanjing 210095, China.
Ruihua HuangInstitute of Swine Science, Nanjing Agricultural University, Nanjing 210095, China.
Maria BallesterAnimal Breeding and Genetics Programme, Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Torre Marimon, Caldes de Montbui 08140, Spain.
Daniel Crespo-PiazueloAnimal Breeding and Genetics Programme, Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Torre Marimon, Caldes de Montbui 08140, Spain.
Marcel AmillsDepartment of Animal Genetics, Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, Campus de la Universitat Autònoma de Barcelona, Bellaterra 08193, Spain.
Alex ClopDepartment of Animal Genetics, Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, Campus de la Universitat Autònoma de Barcelona, Bellaterra 08193, Spain.ORCID https://orcid.org/0000-0001-9238-2728
Peter Karlskov-MortensenAnimal Genetics and Breeding, Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg C 1870, Denmark.
Merete FredholmAnimal Genetics and Breeding, Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg C 1870, Denmark.
Guoqing TangKey Laboratory of Agricultural Bioinformatics, Ministry of Education, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Mingzhou LiKey Laboratory of Agricultural Bioinformatics, Ministry of Education, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.ORCID https://orcid.org/0000-0001-8681-7684
Xuewei LiKey Laboratory of Agricultural Bioinformatics, Ministry of Education, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Xiangdong DingCollege of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Jiaqi LiState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Yaosheng ChenState Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.ORCID https://orcid.org/0000-0002-3871-7651
Qin ZhangCollege of Animal Science and Technology, Shandong Agricultural University, Tai'an 271018, China.ORCID https://orcid.org/0000-0002-7551-5020
Yunxiang ZhaoCollege of Animal Science and Technology, Guangxi University, Nanning 530004, China.
Fuping ZhaoInstitute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.ORCID https://orcid.org/0000-0001-9582-5993
Lingzhao FangCenter for Quantitative Genetics and Genomics (QGG), Aarhus University, Aarhus 8000, Denmark.
Zhe ZhangState Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.ORCID https://orcid.org/0000-0001-7338-7718
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the molecular and cellular mechanisms underlying complex traits in pigs is crucial for enhancing genetic gain via artificial selection and utilizing pigs as models for human disease and biology. Here, we conducted comprehensive genome-wide association studies (GWAS) followed by a cross-breed meta-analysis for 232 complex traits and a within-breed meta-analysis for 12 traits, using 28.3 million imputed sequence variants in 70 328 animals across 14 pig breeds. We identified 6878 quantitative trait loci (QTL) for 139 complex traits. Leveraging the Pig Genotype-Tissue Expression resource, we systematically investigated the biological context and regulatory mechanisms behind these trait-QTLs, ultimately prioritizing 14 829 variant-gene-tissue-trait regulatory circuits. For instance, rs344053754 regulates
Indexed as
complex traitsmeta-GWASmolQTLpigPigGTEx
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