ArticleFrontiers in oncology2025
Additional diagnostic value of ratio indices of quantitative contrast-enhanced ultrasound parameters in small solid C-TIRADS 4 thyroid nodules.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: To investigate the efficacy of contrast-enhanced ultrasound (CEUS) parameters, particularly ratio indices of quantitative CEUS parameters, for differentiation of small solid C-TIRADS 4 thyroid nodules. Materials and methods: 235 small solid C-TIRADS 4 thyroid nodules with determinate pathological results, including 175 nodules in the training cohort and 60 nodules in the validation cohort were retrospectively evaluated. The ratio indices of the internal tissue to peripheral tissue and the internal tissue to healthy tissue of quantitative parameters were calculated. In the training cohort, the meaningful quantitative ratio indices with an AUC > 0.7 and qualitative parameters were further included in multivariate regression analysis. The diagnostic efficacy of the logistic model was evaluated. Results: In single-factor analysis, C-TIRADS, enhancement degree, mTTI ratio (L/P), TTP ratio (L/P), WiR ratio (L/P), WoR ratio (L/P) and TTP ratio (L/H) were significant parameters for differentiation of thyroid nodules (P < 0.05). The multifactor analysis showed that there was significant difference in C-TIRADS, mTTI ratio (L/P), TTP ratio (L/P), WiR ratio (L/P), WoR ratio (L/P) and TTP ratio (L/H) between two groups (P < 0.05). The logistic model was generated, and the AUC, sensitivity, specificity, and accuracy of the training cohort were 0.935(95% CI: 0.888-0.967),85.71%, 88.57%, and 86.86%, respectively. The logistic model demonstrated significantly higher diagnostic performance compared to individual parameters (P < 0.001). In the validation cohort, the diagnostic model had an AUC of 0.910,sensitivity of 87.9%, specificity of 92.6%, and accuracy of 90.25%. Conclusion: Ratio indices of quantitative parameters have high diagnostic values in differentiating small solid thyroid nodules. Combining C-TIRADS with both qualitative and quantitative CEUS parameters enhances the diagnostic accuracy of malignant thyroid nodules.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.