ReviewFrontiers in oncology2025
The influence of beam parameters on FLASH effect.
Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Expanding dose and dose-rate capabilities of a synchrotron-based pre-clinical proton FLASH irradiation platform.Medical physics · 2026Article
- Reduced corneal toxicity following whole brain irradiation in mice.Clinical and translational radiation oncology · 2026Article
- Article
- FLASH radiotherapy as an emerging paradigm in radioimmunotherapy: biological rationale, preclinical evidence, and translational roadmap.Frontiers in immunology · 2026Review
- Advances in proton therapy technology and global clinical applications.Frontiers in oncology · 2026Review
- The potential and risks of FLASH radiotherapy in pediatric patients.Neuro-oncology pediatrics · 2026Review
- Preclinical validation of a clinical prototype of intraoperative electron FLASH radiotherapy equipment: key evidence for a new radiotherapy paradigm.Radiation oncology (London, England) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultra-high dose rate radiotherapy (FLASH-RT) is typically defined as an external beam radiotherapy that utilizes a dose rate of 40 Gy/s or higher, compared with conventional dose rate radiotherapy (≤0.1 Gy/s). The primary advantage of FLASH-RT lies in its ability to minimize damage to organs at risk surrounding the cancer while preserving the anti-tumor effect. This phenomenon, known as the FLASH effect, has been widely studied in various bodily systems. However, recent publication of negative research findings related to FLASH-RT warrant a reassessment of whether this definition is accurate. Therefore, this review aims to critically examine how various beam parameters impact the manifestation of the FLASH effect. Following extensive literature review, we propose that an average dose rate of 40 Gy/s to be the lowest dose that triggers the FLASH effect. Beyond this threshold, different organs, including the brain, lungs, intestine, and skin, required varying minimum single total doses to trigger FLASH effects, with a trend of enhanced FLASH-RT protective effects as the single total doses increased. Moreover, single or multiple pulses and the characteristic parameters of the pulse structure, including single pulse dosage, pulse width, pulse interval, pulse frequency, and total irradiation time, were found to also impact the FLASH effect.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.