Evidence map›Paper›PMID 40330883›Full record

ArticleiScience2025

Roles of class III phosphatidylinositol 3-kinase, Vps34, in phagocytosis, autophagy, and endocytosis in retinal pigmented epithelium.

Feng He, Ralph M Nichols, Melina A Agosto, Theodore G Wensel

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Feng HeDepartment of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA.
Ralph M NicholsDepartment of Ophthalmology, Baylor College of Medicine, Houston, TX, USA.
Melina A AgostoRetina and Optic Nerve Research Laboratory, Department of Physiology and Biophysics, and Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, NS, Canada.
Theodore G WenselDepartment of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA.

Funding

Cilium-Associated Structures in Rod CellsR01EY026545 · NEI · BAYLOR COLLEGE OF MEDICINE · PI WENSEL, THEODORE G · 2016 to 2024
$3.7M
How are necrotic neurons recognized by their phagocytesR01NS129847 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Zheng Zhou · 2022 to 2026
$2.2M
REGULATION AND FUNCTION OF RETINAL PHOSPHOINOSITIDESR01EY031949 · NEI · BAYLOR COLLEGE OF MEDICINE · PI WENSEL, THEODORE G · 2020 to 2023
$1.6M
NEI NIH HHS R01 EY026545NEI NIH HHS R01 EY031949NINDS NIH HHS R01 NS129847
6 · The paper itself

Abstract

Phosphatidylinositol-3-phosphate (PI(3)P) is important for multiple functions of retinal pigmented epithelial (RPE) cells, but its functions in RPE have not been studied. In RPE from mouse eyes and in cultured human RPE cells, PI(3)P-enriched membranes include endosomes, the

Indexed as

EnzymologyFunctional aspects of cell biologyLipidMembranesModel organism

Identifiers

PMID40330883
PMCPMC12052997

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.