Article3 Biotech2025
Huoxiang Zhengqi decoction ameliorates gastrointestinal disorders induced by cold and humid environmental stress via modulation of intestinal mucosal microbiota and amino acid metabolism.
Article in 3 Biotech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Impact of Huoxiang Zhengqi oral liquid on the performance, egg quality, antioxidant capacity via reshaping gut microbiota in laying hens under acute heat stress.Poultry science · 2026Article
- The Role and Potential Mechanism of Pectin and Pectin Oligosaccharides in Treating Intestinal Inflammation by Regulating Gut Microbiota.Probiotics and antimicrobial proteins · 2026Review
- The Interplay Among Gut Microbial Composition, Short-Chain Fatty Acid Metabolism and Gut-Kidney Oxidative Stress: Correlation with Diarrhea.Journal of inflammation research · 2026Article
- Progress in traditional Chinese medicine for chemotherapy-induced nausea and vomiting, based on the theory of "Fuzheng Quxie" and "Hewei Jiangni".American journal of translational research · 2026Review
- Intestinal Microbiota Dysbiosis Disrupts the Mucosal Barrier, Triggering Inflammatory Responses in Gut-Kidney Interaction and Exacerbating Diarrhea.Journal of inflammation research · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigates the intestinal microecological mechanisms of Huoxiang Zhengqi (HXZQ) and its potential clinical applications in alleviating gastrointestinal (GI) disorders caused by cold and humid exposure. In this study, an animal model of cold exposure with GI disorders was prepared by simulating cold and humid environmental stress (CHS). Using this model, PacBio HiFi sequencing of intestinal mucosa full-length 16S rRNA and LC-MS targeted amino acid metabolomic analysis were conducted. An interaction network between the two was constructed to assess the microecological mechanism of intervention by HXZQ. Results indicate that HXZQ accelerates the recovery of GI disorders and restores the integrity of the mucus barrier in CHS mice. PacBio HiFi full-length sequencing of intestinal mucosa suggested that HXZQ can regulate the homeostasis of intestinal mucosal microbiota in CHS mice by promoting the proliferation of probiotics such as Supplementary Information: The online version contains supplementary material available at 10.1007/s13205-025-04324-3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.