Evidence map›Paper›PMID 40331055›Full record

ArticleEnvironmental epidemiology (Philadelphia, Pa.)2025

The association of prenatal ambient air pollution with placental epigenetic gestational age at birth.

Zhengting He, Ashley Y Song, Rose Schrott, Jason I Feinberg, Kelly M Bakulski, Kelly S Benke, Lisa A Croen, Irva Hertz-Picciotto, Rebecca J Schmidt, Kristen Lyall and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental epidemiology (Philadelphia, Pa.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhengting HeDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.ORCID https://orcid.org/0000-0003-4781-3757
Ashley Y SongWendy Klag Center for Autism and Developmental Disabilities, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.ORCID https://orcid.org/0000-0002-1663-5751
Rose SchrottDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Jason I FeinbergWendy Klag Center for Autism and Developmental Disabilities, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.ORCID https://orcid.org/0000-0002-6556-3635
Kelly M BakulskiDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan.ORCID https://orcid.org/0000-0002-9605-6337
Kelly S BenkeWendy Klag Center for Autism and Developmental Disabilities, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Lisa A CroenDivision of Research, Kaiser Permanente Northern California, Pleasanton, California.ORCID https://orcid.org/0000-0001-7849-9428
Irva Hertz-PicciottoDepartment of Public Health Sciences, School of Medicine, University of California at Davis (UC Davis), Davis, California.ORCID https://orcid.org/0000-0001-6952-2390
Rebecca J SchmidtDepartment of Public Health Sciences, School of Medicine, University of California at Davis (UC Davis), Davis, California.
Kristen LyallAJ Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania.ORCID https://orcid.org/0000-0002-4633-0799
Craig J NewschafferCollege of Health and Human Development, Pennsylvania State University, State College, Pennsylvania.
M Daniele FallinRollins School of Public Health, Emory University, Atlanta, Georgia.
Heather E VolkWendy Klag Center for Autism and Developmental Disabilities, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Christine Ladd-AcostaDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.ORCID https://orcid.org/0000-0002-7697-3998

Funding

Research Experiences and Training Coordination CoreP42ES017198 · NIEHS · NORTHEASTERN UNIVERSITY · PI HARRIS, SEAN M · 2010 to 2024
$38.6M
Early Autism Risk Longitudinal Investigation (EARLI) NetworkR01ES016443 · NIEHS · DREXEL UNIVERSITY · PI NEWSCHAFFER, CRAIG J · 2008 to 2013
$15.6M
Environment, The Perinatal Epigenome, and Risk for Autism and Related DisordersR01ES017646 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI FALLIN, M DANIELE, FEINBERG, ANDREW P. · 2009 to 2013
$8.7M
Prenatal exposure to metals and risk for Autism Spectrum Disorder in MARBLES and EARLIR01ES025531 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI VOLK, HEATHER E · 2016 to 2020
$3.2M
Folic Acid Prevention Pathways for ASD in High Risk FamiliesR01ES025574 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SCHMIDT, REBECCA JEAN · 2015 to 2019
$3.1M
Prospective Evaluation of Air Pollution, Cognition, and Autism from Birth OnwardR01ES023780 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VOLK, HEATHER E · 2014 to 2017
$3.0M
Expanding the Value of the EARLI study: Small Cohort with Big DataR24ES030893 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI VOLK, HEATHER E · 2020 to 2024
$2.0M
NIEHS NIH HHS P42 ES017198NIEHS NIH HHS R01 ES016443NIEHS NIH HHS R01 ES017646NIEHS NIH HHS R01 ES023780NIEHS NIH HHS R01 ES025531NIEHS NIH HHS R01 ES025574NIEHS NIH HHS R24 ES030893
6 · The paper itself

Abstract

Background: Prenatal air pollutants have been associated with adverse birth outcomes, and DNA methylation (DNAm) changes in placenta may contribute to these associations. DNAm-based epigenetic gestational age (GA) estimators are emerging biomarkers for aging/biological age that can reflect early-life exposures and predict long-term health outcomes. We leveraged 103 mother-offspring pairs from the Early Autism Risk Longitudinal Investigation cohort to assess associations between prenatal air pollution and placental epigenetic GA at birth. Methods: Prenatal air pollution concentrations (NO Results: Higher pregnancy average O Conclusions: Prenatal air pollution exposures, especially during mid- to late-pregnancy, were associated with lower biological maturity at birth.

Indexed as

Air pollutionDNA methylationEpigenetic agingPlacenta

Identifiers

PMID40331055
PMCPMC12055125

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.