Evidence map›Paper›PMID 40331153›Full record

ArticleMaterials today. Bio2025

Sequential SDF-1/CGRP-releasing smart composite hydrogel promotes osteoporotic fracture healing by targeting sensory nerve-regulated bone remodeling.

Yuan Wang, Zhen Pan, Qianliang Wang, Yuexia Shu, Zhenyu Tan, Yujie Chen, Jieming He, Jia Wang, Jielin Wang, Jun Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuan WangDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Zhen PanDepartment of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200235, China.
Qianliang WangDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Yuexia ShuDepartment of Orthopedics, TongRen Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, 200336, China.
Zhenyu TanDepartment of Pathology, Tongji Hospital, Tongji University, Shanghai, 200065, China.
Yujie ChenDepartment of Orthopedics, TongRen Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, 200336, China.
Jieming HeDepartment of Orthopedics, TongRen Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, 200336, China.
Jia WangDepartment of Orthopedics, TongRen Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, 200336, China.
Jielin WangDepartment of Orthopedics, TongRen Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, 200336, China.
Jun YanDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporotic fractures typically exhibit delayed healing due to impaired cell recruitment, chronic inflammation, and disrupted neurovascular signaling. Sensory nerve signaling plays a crucial role in fracture repair, and its deficiency is a significant factor leading to delayed healing. Addressing these deficiencies is crucial to overcoming the challenges associated with delayed bone repair in osteoporosis. In this study, a smart composite hydrogel (denoted as OCS-MPC) was synthesized by embedding CGRP-functionalized polydopamine-coated MXene nanosheets (MXene/PDA/CGRP) into boronic acid-modified oxidized hyaluronic acid-crosslinked carboxymethyl chitosan (OHA-PBA/CMCS) hydrogel loaded with SDF-1. OCS-MPC hydrogel enables the controlled release of SDF-1 and CGRP, aiming to promote early callus formation and late-stage callus remodeling in osteoporotic fractures. Due to dynamic crosslinking via imine and borate ester bonds, OCS-MPC exhibits rapid gelation, injectability, and self-healing properties. In vitro experiments demonstrated excellent osteogenic, angiogenic, and neurogenic properties of OCS-MPC hydrogel. In vivo studies using an osteoporotic femoral fracture model showed that OCS-MPC hydrogel enhanced MSCs recruitment via the SDF-1/CXCR4 signaling axis, significantly improving callus formation in the early stages of fracture repair. Additionally, OCS-MPC hydrogel significantly promoted callus mineralization and remodeling in the later stages of osteoporotic fracture healing through enhancing CGRP signaling. Immunofluorescence analysis further confirmed increased expression of TUBB3, CGRP, and CD31, indicating successful regeneration of the neurovascular network. These findings highlight the potential of OCS-MPC hydrogel in addressing both early and late-stage challenges of osteoporotic fracture healing, providing a promising therapeutic strategy for enhancing bone regeneration in osteoporotic patients.

Indexed as

Callus remodelingFracture healingOsteoporotic fracturesSensory nervesSmart hydrogel

Identifiers

PMID40331153
PMCPMC12054128

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.