Evidence map›Paper›PMID 40331222›Full record

ArticleFrontiers in veterinary science2025

Newcastle disease virus expressing clade 2.3.4.4b H5 hemagglutinin confers protection against lethal H5N1 highly pathogenic avian influenza in BALB/c mice.

Deok-Hwan Kim, Seung-Hun Lee, Jiwon Kim, Jiho Lee, Ji-Hun Lee, Jei-Hyun Jeong, Ji-Yun Kim, Yang-Kyu Choi, Sungsu Youk, Chang-Seon Song

Abstract read
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In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Deok-Hwan KimAvian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Seung-Hun LeeKHAV Co., Ltd., Seoul, Republic of Korea.
Jiwon KimKHAV Co., Ltd., Seoul, Republic of Korea.
Jiho LeeSoutheast Poultry Research Laboratory, U.S. Department of Agriculture-Agricultural Research Service, U.S. National Poultry Research Center, Athens, GA, United States.
Ji-Hun LeeDepartment of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Jei-Hyun JeongAvian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Ji-Yun KimKHAV Co., Ltd., Seoul, Republic of Korea.
Yang-Kyu ChoiDepartment of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Sungsu YoukDepartment of Microbiology, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea.
Chang-Seon SongAvian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The widespread H5 clade 2.3.4.4b highly pathogenic avian influenza virus (HPAI) poses a significant threat to both domestic and wild mammals because of its rapid genetic evolution, cross-species transmissibility, and host-range expansion. The increasing number of cases in mammalian species highlights the need for proactive measures driven by the One Health approach. In this study, we explored the potential use of previously developed a Newcastle disease virus (NDV)-vectored vaccine expressing clade 2.3.4.4b H5 hemagglutinin (rK148/22-H5) in a preclinical BALB/c mouse model. Two doses of intramuscular vaccination with viable (10

Indexed as

H5N1 clade 2.3.4.4bhigh pathogenic avian influenzalung and brain viral loadmammalian infection and transmissionNewcastle disease virus-vectored vaccine

Identifiers

PMID40331222
PMCPMC12053158

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.