Evidence map›Paper›PMID 40331365›Full record

Observational studyMovement disorders clinical practice2025

Long-Term Outcomes in a Parkinson's Disease Minor Phenomena Cohort.

Ruth B Schneider, Anisha Singh, Miriam T Weber, Anneliese T Elmer, Katherine Amodeo, Karlo J Lizarraga, Irene H Richard, Michael P McDermott

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ruth B SchneiderDepartment of Neurology, University of Rochester, Rochester, New York, USA.ORCID https://orcid.org/0000-0001-8094-4041
Anisha SinghDepartment of Neurology, University of Rochester, Rochester, New York, USA.
Miriam T WeberDepartment of Neurology, University of Rochester, Rochester, New York, USA.
Anneliese T ElmerDepartment of Neurology, University of Rochester, Rochester, New York, USA.
Katherine AmodeoDepartment of Neurology, University of Rochester, Rochester, New York, USA.
Karlo J LizarragaDepartment of Neurology, University of Rochester, Rochester, New York, USA.
Irene H RichardDepartment of Neurology, University of Rochester, Rochester, New York, USA.
Michael P McDermottDepartment of Neurology, University of Rochester, Rochester, New York, USA.

Funding

ACADIA Pharmaceuticals
6 · The paper itself

Abstract

backgroundMinor phenomena, including illusions, feeling of presence, and passage hallucinations, are common in Parkinson's disease (PD) and may be a risk factor for the development of psychosis (hallucinations and delusions).

objectivesThe objective of this study was to determine the 3-year cumulative probability of developing psychosis among individuals with PD minor phenomena.

methodsWe conducted a 3-year, prospective, observational study of individuals with PD minor phenomena with biannual study visits. The presence of psychosis was ascertained using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part I Hallucinations and Psychosis item and the enhanced Scale for the Assessment of Positive Symptoms in PD (eSAPS-PD). The primary outcome variable was the time from baseline to the development of psychosis. Proportional hazards regression models were applied to examine potential risk factors for the development of psychosis.

resultsWe enrolled 38 individuals with PD minor phenomena and included 34 in the primary analysis (47% female with mean standard deviation [SD]), with age 70.3 (7.9) years and mean (SD) time from PD diagnosis 7.5 (5.9) years). Twenty-four (71%) of the 34 developed psychosis during follow-up. None of the examined demographic or clinical variables were associated with the time to development of psychosis.

conclusionsOver a 3-year period, there was a high cumulative probability of psychosis among individuals with PD minor phenomena in this single-center prospective study.

Indexed as

DelusionsHallucinationsParkinson DiseasePsychotic DisordersAgedCohort StudiesFemaleHumansMaleMiddle AgedProspective StudiesPsychiatric Status Rating ScalesRisk Factorsminor hallucinationsminor phenomenaParkinson's diseasepsychosis

Identifiers

PMID40331365
PMCPMC12528953

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.