Evidence map›Paper›PMID 40331369›Full record

ArticlePharmaceutical biology2025

Tanshinone IIA reduces tubulointerstitial fibrosis by suppressing GSDMD-mediated pyroptosis.

Xueling Yang, Qinglin Luo, Zhifen Wu, Chunxuan Wang, Yuanjing Yang, Luquan Zheng, Ke Li, Lei Zhao, Yang Jurong

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PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xueling YangDepartment of Nephrology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Qinglin LuoDepartment of Nephrology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zhifen WuDepartment of Nephrology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chunxuan WangDepartment of Nephrology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yuanjing YangDepartment of Nephrology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Luquan ZhengDepartment of Nephrology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ke LiCore Research Laboratory, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Lei ZhaoDepartment of Nephrology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yang JurongDepartment of Nephrology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextTanshinone IIA (Tan IIA), a bioactive compound derived from the traditional Chinese herb

objectiveThis study aimed to explore the protective effects of Tan IIA in a mouse model of unilateral ureteral obstruction (UUO) and to elucidate the cellular and molecular mechanisms underlying these effects. MATERIALS AND

methodsGasdermin D (GSDMD) knockout mice and their wild-type (WT) littermates underwent UUO surgery, with Tan IIA treatment administered 24 h prior. Human proximal tubular cells (HK-2 cells) were treated with TGF-β1 to induce fibrosis (50 ng/mL for 24 h), followed by Tan IIA treatment (5 μM) for an additional 3 h.

resultsTan IIA significantly reduced the expression of extracellular matrix (ECM) components, including collagen I, α-smooth muscle actin (α-SMA), vimentin and fibronectin, in UUO mice. Tan IIA attenuated GSDMD-mediated pyroptosis. However, in GSDMD knockout mice subjected to UUO, the protective effects of Tan IIA on ECM gene expression and collagen deposition in the tubular interstitium were reduced. DISCUSSION AND

conclusionsTan IIA may mitigate GSDMD-mediated pyroptosis in renal tubular epithelial cells (RTECs) and reduce kidney fibrosis, highlighting its potential as a therapeutic strategy to prevent the progression of kidney disease after ureteral obstruction.

Indexed as

AbietanesIntracellular Signaling Peptides and ProteinsKidney DiseasesPhosphate-Binding ProteinsPyroptosisAnimalsCell LineDisease Models, AnimalFibrosisGasderminsHumansMaleMiceMice, Inbred C57BLMice, KnockoutPore Forming Cytotoxic ProteinsAbietanesGasderminsGsdmd protein, mouseIntracellular Signaling Peptides and ProteinsPhosphate-Binding ProteinsPore Forming Cytotoxic Proteinstanshinonecell deathChinese herbal medicinechronic kidney diseaseGasdermin Dpyroptosisunilateral ureteral obstruction

Identifiers

PMID40331369
PMCPMC12064128

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.