ArticleInternational journal of molecular sciences2025
Can Serum Salusin-α and Salusin-β Serve as Biomarkers for Early Atherosclerotic Lesions in Obese Children?
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Evaluation of Salusin-α and Salusin-β Levels in Human Saliva Samples from Patients with Gingivitis and Periodontitis: A Cross-Sectional Study.Biomedicines · 2026Article
- Diagnostic Performance of Salusins in Acute Pulmonary Embolism: A Prospective Observational Study.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Obesity increases the risk of atherosclerosis. Recent studies highlight the role of salusins, bioactive peptides, in its development. This study aimed to determine the risk factors for premature atherosclerosis in obese children based on obesity severity and assess the usefulness of serum salusin-α and salusin-β as early biomarkers. We examined 125 children with simple obesity, divided into two subgroups by BMI-SDS (I: 2-4, II: >4), and we compared them with 33 healthy-weight peers. Obese children had significantly higher serum salusin-α and salusin-β levels, as well as hsCRP, TG, SBP, DBP, and PWV, compared to controls. Only salusin-α levels increased with obesity severity. Salusin-α correlated with BMI SDS and hsCRP, while salusin-β showed no associations. Our findings suggest that salusin-α could be an early inflammation marker and a predictor of atherosclerosis, pointing to salusin-α, rather than salusin-β, as the earliest marker of atherosclerosis in obese children. Further research is needed to confirm these results.
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Registered trials
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