ArticleMolecular biology of the cell2025
Sec18 ATP hydrolysis selectively releases Sec17 from
Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Functional assembly of the Qc-SNARE with Sec18 and Sec17 on membranes.Molecular biology of the cell · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Intracellular membrane fusion is catalyzed by SNAREs, Rabs, SM proteins, tethers, Sec18/NSF, and Sec17/SNAP. Fusion has two engines, completion of SNARE zippering (without needing Sec17/Sec18) and Sec17/Sec18 (which need SNAREs but not energy from their complete zippering). We have reconstituted membrane fusion with purified vacuolar proteins to address three questions: 1) whether Sec18 ATP hydrolysis affects fusion, 2) whether Sec17 and Sec18 only promote fusion with mutant SNAREs or also work with wild-type SNAREs, and 3) whether Sec17 and Sec18 can separately promote fusion. We find that 1) Sec18 ATP hydrolysis blocks fusion at limiting Sec17 levels by releasing Sec17 without concomitant
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.