Evidence map›Paper›PMID 40332094›Full record

Trial reportInternational journal of molecular sciences2025

Changes in proBDNF and Mature BDNF Levels After Medium-Intensity Functional Motor Rehabilitation Program in Patients with Parkinson's Disease.

Joanna Cholewa, Marta Nowacka-Chmielewska, Agnieszka Gorzkowska, Andrzej Malecki, Anetta Lasek-Bal, Jaroslaw Cholewa

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joanna CholewaInstitute of Sport Sciences, Academy of Physical Education in Katowice, 40-065 Katowice, Poland.
Marta Nowacka-ChmielewskaLaboratory of Molecular Biology, Institute of Physiotherapy and Health Sciences, Academy of Physical Education in Katowice, 40-065 Katowice, Poland.ORCID 0000-0001-8668-8878
Agnieszka GorzkowskaDepartment of Neurology, School of Health Sciences, Medical University of Silesia in Katowice, 40-635 Katowice, Poland.ORCID 0000-0001-5081-8343
Andrzej MaleckiLaboratory of Molecular Biology, Institute of Physiotherapy and Health Sciences, Academy of Physical Education in Katowice, 40-065 Katowice, Poland.
Anetta Lasek-BalDepartment of Neurology, School of Health Sciences, Medical University of Silesia in Katowice, 40-635 Katowice, Poland.ORCID 0000-0003-2481-7528
Jaroslaw CholewaInstitute of Sport Sciences, Academy of Physical Education in Katowice, 40-065 Katowice, Poland.ORCID 0000-0003-2179-5466

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical rehabilitation complements the treatment of Parkinson's disease (PD). The applied physical exercises are effective in PD by promoting activity-dependent neuroplasticity. The main aim of this study was to assess the effect of a 16-week moderate-intensity functional physical rehabilitation program (FPR) on the concentration of mature brain-derived neurotrophic factor (BDNF) and its precursor (proBDNF) in blood serum and the severity of symptoms and quality of life in people with PD. People with PD (Hoehn and Yahr stage 3) were randomly assigned to the experimental (FPR) and control (CG) groups. FPR participated in movement training to improve functional mobility, motor coordination, and balance. Pre- and post-intervention assessments included serum levels of proBDNF, mature BDNF, MDS-UPDRS sub-scales, and the PDQ-39 quality of life measured. In the FPR group, a statistically significant increase in serum proBDNF levels by 39.42% (

Indexed as

Brain-Derived Neurotrophic FactorExercise TherapyParkinson DiseaseProtein PrecursorsAgedFemaleHumansMaleMiddle AgedQuality of LifeBDNF protein, humanBrain-Derived Neurotrophic Factorbrain-derived neurotrophic factor precursorProtein PrecursorsBDNFexerciseParkinson’s diseasephysical rehabilitationproBDNF

Identifiers

PMID40332094
PMCPMC12027431

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.