ArticleRevista da Associacao Medica Brasileira (1992)2025
A new approach to osteoarthritis: gut microbiota.
Article in Revista da Associacao Medica Brasileira (1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Gut and Joint Microbiome and Dysbiosis: A New Perspective on the Pathogenesis and Treatment of Osteoarthritis.Pathogens (Basel, Switzerland) · 2026Review
- Therapeutic effect of modified meridian-guided acupoint pressing on lumbar facet joint osteoarthritis: an integrated microbiomics and metabolomics analysis.Frontiers in medicine · 2026Article
- Gut microbiota and osteoarthritis: mechanisms and translation.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveStudies investigating the relationship between the gut microbiome and osteoarthritis have increased in recent years. However, data on the relationship between joints and the gut microbiome are limited. The aim of this study was to determine whether there is a relation between knee joint fluid and gut microbiota in patients with knee osteoarthritis.
methodsThis study included 40 individuals, 20 of whom were diagnosed with knee osteoarthritis and 20 of whom were considered healthy controls. Joint-fluid and stool samples were taken from the participants. Bacteria isolated from the samples were identified using a matrix-assisted laser desorption ionization-time of flight-mass spectrometry device.
resultsTwenty-nine different bacteria were isolated from the stool samples and five bacteria were isolated from the joint-fluid samples. In our study, the same types of microorganisms (Enterococcus faecium and Staphylococcus hominis) were isolated from the stool and joint-fluid samples.
conclusionThe data obtained in our study shed light on the uncertainty of how microorganisms, especially those identified in the knee and hip in the literature, reach these regions. The presence of intestinal bacteria in the knee joint fluid of osteoarthritis patients indicates that intestinal bacteria, especially in individuals with a weak immune system, malnutrition, and obesity, pass through the intestinal wall and reach other parts of the body via the bloodstream, a condition also known as "leaky gut."
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Registered trials
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