ArticleInternational journal of molecular sciences2025
A Quinoxaline 1,4-Dioxide Activates DNA Repair Systems in
Olga B Bekker, Olesya O Galanova, Aleksey A Vatlin, Svetlana G Frolova, Egor A Shitikov, Dmitry A Bespiatykh, Ksenia M Klimina, Vladimir A Veselovsky, Rustem A Ilyasov, Svetlana V Smirnova and 4 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Olga B BekkerLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.ORCID 0000-0003-2015-0025 Olesya O GalanovaLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.ORCID 0009-0001-3512-9571 Aleksey A VatlinLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.ORCID 0000-0002-6499-3908 Svetlana G FrolovaLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.
Egor A ShitikovDivision of Biomedicine and Genomics, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.ORCID 0000-0002-4865-6004 Dmitry A BespiatykhDivision of Biomedicine and Genomics, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.ORCID 0000-0003-0867-5988 Ksenia M KliminaDivision of Biomedicine and Genomics, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.
Vladimir A VeselovskyDivision of Biomedicine and Genomics, Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.ORCID 0000-0002-4336-9452 Rustem A IlyasovLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.ORCID 0000-0003-2445-4739 Svetlana V SmirnovaLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.
Diana A ReznikovaLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.ORCID 0009-0003-3725-8101 Nikita I KochetkovLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.ORCID 0000-0002-2196-5421 Dmitry A MaslovDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-4296-5815 Valery N DanilenkoLaboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.ORCID 0000-0001-5780-0621 Funding
Government basic research program 0088-2024-0009State assignment from the Ministry of Science of the Russian Federation 0092-2022-0003the RUDN University Scientific Projects Grant System 202760-2-000
6 · The paper itselfAbstract
In 2022, the World Health Organization reported that tuberculosis (TB) was the second leading cause of death globally from a single infectious agent following COVID-19. The development of new antitubercular agents with novel mechanisms of action for use in complex TB therapy is considered a key approach to combating TB. In this study, we examined the gene expression profile of
Indexed as
Antitubercular AgentsDNA RepairMycobacterium smegmatisQuinoxalinesTranscriptomeBacterial ProteinsGene Expression ProfilingGene Expression Regulation, BacterialMicrobial Sensitivity TestsReactive Oxygen SpeciesAntitubercular AgentsBacterial ProteinsQuinoxalinesReactive Oxygen Speciesantituberculosis agentM. smegmatisQdNOstranscriptome
Identifiers
PMID40332345
PMCPMC12027616
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