Evidence map›Paper›PMID 40332879›Full record

ReviewJAMA psychiatry2025

Cross-Species Framework for Emotional Well-Being and Brain Aging: Lessons From Behavioral Neuroscience.

F Vankee Lin, Janine M Simmons, Adam Turnbull, Yi Zuo, Yeates Conwell, Kuan Hong Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in JAMA psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

F Vankee LinDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California.
Janine M SimmonsOffice of Behavioral and Social Sciences Research, National Institutes of Health, Bethesda, Maryland.
Adam TurnbullDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California.
Yi ZuoDepartment of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz.
Yeates ConwellDepartment of Psychiatry, University of Rochester, Rochester, New York.
Kuan Hong WangDepartment of Neuroscience, University of Rochester, Rochester, New York.

Funding

U24 NEW Brain Aging Diversity SupplementU24AG072701 · NIA · UNIVERSITY OF ROCHESTER · PI CONWELL, YEATES, LIN, FENG VANKEE · 2021 to 2024
$2.6M
NIA NIH HHS U24 AG072701
6 · The paper itself

Abstract

Importance: Emotional well-being (EWB) is an emerging therapeutic target for managing and preventing symptoms associated with Alzheimer disease and related dementias (ADRD). However, more research is needed to establish causal inferences between brain changes, EWB, and behavioral changes observed in typical aging and ADRD. Observations: This article presents a framework for using a cross-species behavioral neuroscience approach to study EWB and brain aging, adopting a well-established biobehavioral model that highlights the reciprocal roles of brain changes, EWB, and ADRD symptoms. First, the challenges and opportunities in this field are reviewed. Then, a practical solution to improve comparability between animal and human studies is proposed. Conclusions and Relevance: The goal is to draw comprehensive parallels and distinctions that could enhance the understanding of the mechanisms linking brain aging, EWB, and ADRD symptomatic disturbances across different species.

Indexed as

AgingAlzheimer DiseaseBrainDementiaEmotionsAnimalsHumansNeurosciencesSpecies Specificity

Identifiers

PMID40332879
PMCPMC13508064

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.