ArticleMolecules (Basel, Switzerland)2025
Surface Modification of Gold Nanoparticle Impacts Distinct Lipid Metabolism.
Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
11 authors.
Funding
Abstract
Gold nanomaterials have garnered significant attention in biomedicine owing to their tunable size and morphology, facile surface modification capabilities, and distinctive optical properties. The surface functionalization of these nanoparticles can enhance their safety and efficacy in nanomedical applications. In this study, we examined the biological effects of gold nanoparticles (GNPs) with three distinct surface modifications (polyethylene glycol, chitosan, and polyethylenimine) in murine models, elucidating their mechanisms of action on hepatic tissue at both the transcriptomic and metabolomic levels. Our findings revealed that PEG-modified GNPs did not significantly alter any major metabolic pathway. In contrast, CS-GNPs markedly affected the metabolic pathways of retinol, arachidonic acid, linoleic acid, and glycerophospholipids (FDR < 0.05). Similarly, PEI-GNPs significantly influenced the metabolic pathways of retinol, arachidonic acid, linoleic acid, and sphingolipids (FDR < 0.05). Through a comprehensive analysis of the regulatory information within these pathways, we identified phosphatidylcholine compounds as potential biomarkers that may underlie the differential biological effects of the three functionalized GNPs. These findings provide valuable experimental data for evaluating the biological safety of functionalized GNPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.