ArticlePloS one2025
The positive relationship between the Alternative Healthy Diet Index and serum klotho levels: A cross-sectional analysis in middle-to-older Americans.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Dietary patterns, polygenic risk, and kidney cancer incidence: a UK Biobank cohort study.Journal of translational medicine · 2025Article
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5 authors.
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Abstract
BACKGROUND AND
aimThe Alternative Healthy Eating Index (AHEI-2010) is a dietary index associated with chronic diseases and serves as an important metric for assessing the healthiness of one's diet. Serum Soluble Klotho (S-Klotho) is a protein related to anti-aging. There is currently a lack of research on the relationship between AHEI and S-Klotho. This study evaluated the relationship between the AHEI index and S-Klotho in the U.S. middle-aged and elderly population from the National Health and Nutrition Examination Survey (NHANES) 2011-2016. METHODOLOGY: This study includes 6,305 middle-aged and elderly participants (aged 40-79 years old). The interrelationship between the AHEI-2010 and S-klotho concentration was explored using multivariate regression models, and the nonlinear relationship between the two was investigated through curve fitting. The stability of this relationship in different populations was explored through subgroup analysis.
resultsThere was a positive correlation between AHEI and S-klotho (β=1.1, 95% CI: 0.1, 2.1, P = 0.035). The multivariate-adjusted β and 95% confidence intervals (CIs) from the lowest to the highest AHEI-2010 categories (＜31.9, 31.9-39.3, 39.3-47.9, and > 47.9) were 0.0 (reference), 15.7 (-13.5, 44.9), 12.5 (-16.5, 41.6), and 31.9 (2.9, 60.9), respectively. The curve fitting found that the relationship between AHEI-2010 and S-Klotho is essentially linear, with S-Klotho levels increasing linearly as AHEI improves.
conclusionAHEI is positively associated with S-Klotho levels in American middle-to-older adults. Further research is needed to elucidate the causal relationship and specific mechanisms.
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